New antibacterial sesquiterpene aminoquinones from a Vietnamese marine sponge of Spongia sp.

Hien Minh Nguyen; Takuya Ito; Nwet Nwet Win; Takeshi Kodama; Vo Quoc Hung; Hoai Thi Nguyen; Hiroyuki Morita

doi:10.1016/j.phytol.2016.08.012

New antibacterial sesquiterpene aminoquinones from a Vietnamese marine sponge of Spongia sp.

Hien Minh Nguyen, Takuya Ito^*, Nwet Nwet Win, Takeshi Kodama, Vo Quoc Hung, Hoai Thi Nguyen, Hiroyuki Morita

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Two new sesquiterpene aminoquinones, langcoquinones A (1) and B (2), together with seven known meroterpenoids (3–9), were isolated from the marine sponge Spongia sp. collected in Vietnam. Their structures were determined on the basis of spectroscopic analyses and comparisons with published data. The antibacterial activities of the isolated compounds (1–9) were investigated against four bacterial strains. Among these, the new sesquiterpene aminoquinones (1 and 2) and the known related compounds (3, 5, 6, 8, and 9) exhibited significant antibacterial activities against Staphylococcus aureus and Bacillus subtilis, with MICs ranging from 6.25 to 12.5 μM.

Original language	English
Pages (from-to)	288-292
Number of pages	5
Journal	Phytochemistry Letters
Volume	17
DOIs	https://doi.org/10.1016/j.phytol.2016.08.012
State	Published - 2016/09/01

Keywords

4,9-Friedodrimane
Antibacterial activities
Marine sponge
Sesquiterpene aminoquinone
Smenospongine
Spongia sp.

ASJC Scopus subject areas

Biotechnology
Biochemistry
Agronomy and Crop Science
Plant Science

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10.1016/j.phytol.2016.08.012

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title = "New antibacterial sesquiterpene aminoquinones from a Vietnamese marine sponge of Spongia sp.",

abstract = "Two new sesquiterpene aminoquinones, langcoquinones A (1) and B (2), together with seven known meroterpenoids (3–9), were isolated from the marine sponge Spongia sp. collected in Vietnam. Their structures were determined on the basis of spectroscopic analyses and comparisons with published data. The antibacterial activities of the isolated compounds (1–9) were investigated against four bacterial strains. Among these, the new sesquiterpene aminoquinones (1 and 2) and the known related compounds (3, 5, 6, 8, and 9) exhibited significant antibacterial activities against Staphylococcus aureus and Bacillus subtilis, with MICs ranging from 6.25 to 12.5 μM.",

keywords = "4,9-Friedodrimane, Antibacterial activities, Marine sponge, Sesquiterpene aminoquinone, Smenospongine, Spongia sp.",

author = "Nguyen, {Hien Minh} and Takuya Ito and Win, {Nwet Nwet} and Takeshi Kodama and Hung, {Vo Quoc} and Nguyen, {Hoai Thi} and Hiroyuki Morita",

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doi = "10.1016/j.phytol.2016.08.012",

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T1 - New antibacterial sesquiterpene aminoquinones from a Vietnamese marine sponge of Spongia sp.

AU - Nguyen, Hien Minh

AU - Ito, Takuya

AU - Win, Nwet Nwet

AU - Kodama, Takeshi

AU - Hung, Vo Quoc

AU - Nguyen, Hoai Thi

AU - Morita, Hiroyuki

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Two new sesquiterpene aminoquinones, langcoquinones A (1) and B (2), together with seven known meroterpenoids (3–9), were isolated from the marine sponge Spongia sp. collected in Vietnam. Their structures were determined on the basis of spectroscopic analyses and comparisons with published data. The antibacterial activities of the isolated compounds (1–9) were investigated against four bacterial strains. Among these, the new sesquiterpene aminoquinones (1 and 2) and the known related compounds (3, 5, 6, 8, and 9) exhibited significant antibacterial activities against Staphylococcus aureus and Bacillus subtilis, with MICs ranging from 6.25 to 12.5 μM.

AB - Two new sesquiterpene aminoquinones, langcoquinones A (1) and B (2), together with seven known meroterpenoids (3–9), were isolated from the marine sponge Spongia sp. collected in Vietnam. Their structures were determined on the basis of spectroscopic analyses and comparisons with published data. The antibacterial activities of the isolated compounds (1–9) were investigated against four bacterial strains. Among these, the new sesquiterpene aminoquinones (1 and 2) and the known related compounds (3, 5, 6, 8, and 9) exhibited significant antibacterial activities against Staphylococcus aureus and Bacillus subtilis, with MICs ranging from 6.25 to 12.5 μM.

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KW - Antibacterial activities

KW - Marine sponge

KW - Sesquiterpene aminoquinone

KW - Smenospongine

KW - Spongia sp.

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JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

New antibacterial sesquiterpene aminoquinones from a Vietnamese marine sponge of Spongia sp.

Abstract

Keywords

ASJC Scopus subject areas

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