New antibacterial sesquiterpene aminoquinones from a Vietnamese marine sponge of Spongia sp.

Hien Minh Nguyen; Takuya Ito; Nwet Nwet Win; Takeshi Kodama; Vo Quoc Hung; Hoai Thi Nguyen; Hiroyuki Morita

doi:10.1016/j.phytol.2016.08.012

New antibacterial sesquiterpene aminoquinones from a Vietnamese marine sponge of Spongia sp.

Hien Minh Nguyen, Takuya Ito^*, Nwet Nwet Win, Takeshi Kodama, Vo Quoc Hung, Hoai Thi Nguyen, Hiroyuki Morita

^*この論文の責任著者

和漢医薬学総合研究所研究開発部門資源開発分野（天然物創薬学領域）

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

19 被引用数 (Scopus)

抄録

Two new sesquiterpene aminoquinones, langcoquinones A (1) and B (2), together with seven known meroterpenoids (3–9), were isolated from the marine sponge Spongia sp. collected in Vietnam. Their structures were determined on the basis of spectroscopic analyses and comparisons with published data. The antibacterial activities of the isolated compounds (1–9) were investigated against four bacterial strains. Among these, the new sesquiterpene aminoquinones (1 and 2) and the known related compounds (3, 5, 6, 8, and 9) exhibited significant antibacterial activities against Staphylococcus aureus and Bacillus subtilis, with MICs ranging from 6.25 to 12.5 μM.

本文言語	英語
ページ（範囲）	288-292
ページ数	5
ジャーナル	Phytochemistry Letters
巻	17
DOI	https://doi.org/10.1016/j.phytol.2016.08.012
出版ステータス	出版済み - 2016/09/01

ASJC Scopus 主題領域

バイオテクノロジー
生化学
農業および作物学
植物科学

文献へのアクセス

10.1016/j.phytol.2016.08.012

引用スタイル

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title = "New antibacterial sesquiterpene aminoquinones from a Vietnamese marine sponge of Spongia sp.",

abstract = "Two new sesquiterpene aminoquinones, langcoquinones A (1) and B (2), together with seven known meroterpenoids (3–9), were isolated from the marine sponge Spongia sp. collected in Vietnam. Their structures were determined on the basis of spectroscopic analyses and comparisons with published data. The antibacterial activities of the isolated compounds (1–9) were investigated against four bacterial strains. Among these, the new sesquiterpene aminoquinones (1 and 2) and the known related compounds (3, 5, 6, 8, and 9) exhibited significant antibacterial activities against Staphylococcus aureus and Bacillus subtilis, with MICs ranging from 6.25 to 12.5 μM.",

keywords = "4,9-Friedodrimane, Antibacterial activities, Marine sponge, Sesquiterpene aminoquinone, Smenospongine, Spongia sp.",

author = "Nguyen, {Hien Minh} and Takuya Ito and Win, {Nwet Nwet} and Takeshi Kodama and Hung, {Vo Quoc} and Nguyen, {Hoai Thi} and Hiroyuki Morita",

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T1 - New antibacterial sesquiterpene aminoquinones from a Vietnamese marine sponge of Spongia sp.

AU - Nguyen, Hien Minh

AU - Ito, Takuya

AU - Win, Nwet Nwet

AU - Kodama, Takeshi

AU - Hung, Vo Quoc

AU - Nguyen, Hoai Thi

AU - Morita, Hiroyuki

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Two new sesquiterpene aminoquinones, langcoquinones A (1) and B (2), together with seven known meroterpenoids (3–9), were isolated from the marine sponge Spongia sp. collected in Vietnam. Their structures were determined on the basis of spectroscopic analyses and comparisons with published data. The antibacterial activities of the isolated compounds (1–9) were investigated against four bacterial strains. Among these, the new sesquiterpene aminoquinones (1 and 2) and the known related compounds (3, 5, 6, 8, and 9) exhibited significant antibacterial activities against Staphylococcus aureus and Bacillus subtilis, with MICs ranging from 6.25 to 12.5 μM.

AB - Two new sesquiterpene aminoquinones, langcoquinones A (1) and B (2), together with seven known meroterpenoids (3–9), were isolated from the marine sponge Spongia sp. collected in Vietnam. Their structures were determined on the basis of spectroscopic analyses and comparisons with published data. The antibacterial activities of the isolated compounds (1–9) were investigated against four bacterial strains. Among these, the new sesquiterpene aminoquinones (1 and 2) and the known related compounds (3, 5, 6, 8, and 9) exhibited significant antibacterial activities against Staphylococcus aureus and Bacillus subtilis, with MICs ranging from 6.25 to 12.5 μM.

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KW - Marine sponge

KW - Sesquiterpene aminoquinone

KW - Smenospongine

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New antibacterial sesquiterpene aminoquinones from a Vietnamese marine sponge of Spongia sp.

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