Heptaoxygenated xanthones as anti-austerity agents from Securidaca longepedunculata

Dya Fita Dibwe, Suresh Awale, Shigetoshi Kadota, Hiroyuki Morita, Yasuhiro Tezuka*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

In a course of our search for anticancer agent based on a novel anti-austerity strategy, we found that the CHCl3 extract of the roots of Securidaca longepedunculata (Polygalaceae), collected at Democratic Republic of Congo, killed PANC-1 human pancreatic cancer cells preferentially in nutrient-deprived medium (NDM). Phytochemical investigation on the CHCl 3 extract led to the isolation of 28 compounds including five new polymethoxylated xanthones [1,6,8-trihydroxy-2,3,4,5-tetramethoxyxanthone (1), 1,6-dihydroxy-2,3,4,5,8-pentamethoxyxanthone (2), 8-hydroxy-1,4,5,6- tetramethoxy-2,3-methylenedioxyxanthone (3), 4,6,8-trihydroxy-1,2,3,5- tetramethoxyxanthone (4), 4,8-dihydroxy-1,2,3,5,6-pentamethoxyxanthone (5)] and a new benzyl benzoate [benzyl 3-hydroxy-2-methoxybenzoate (6)]. Among them, 1,6,8-trihydroxy-2,3,4,5-tetramethoxyxanthone (1) and 1,6-dihydroxy-2,3,4,5,8- pentamethoxyxanthone (2) displayed the potent preferential cytotoxicity with PC50 of 22.8 and 17.4 μM, respectively. They triggered apoptosis-like PANC-1 cell death in NDM with a glucose-sensitive mode.

Original languageEnglish
Pages (from-to)7663-7668
Number of pages6
JournalBioorganic and Medicinal Chemistry
Volume21
Issue number24
DOIs
StatePublished - 2013/12/15

Keywords

  • Congolese medicinal plant
  • Pancreatic cancer
  • Preferential cytotoxicity
  • Securidaca longepedunculata
  • Xanthone

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Heptaoxygenated xanthones as anti-austerity agents from Securidaca longepedunculata'. Together they form a unique fingerprint.

Cite this