TY - JOUR
T1 - Heptaoxygenated xanthones as anti-austerity agents from Securidaca longepedunculata
AU - Dibwe, Dya Fita
AU - Awale, Suresh
AU - Kadota, Shigetoshi
AU - Morita, Hiroyuki
AU - Tezuka, Yasuhiro
N1 - Funding Information:
Parts of this work were supported by a grant from the Ministry of Health and Welfare for the Third Term Comprehensive 10 Year Strategy for Cancer Control and a research program of the Project for Development of Innovative Research on Cancer Therapeutics (P-Direct) .
PY - 2013/12/15
Y1 - 2013/12/15
N2 - In a course of our search for anticancer agent based on a novel anti-austerity strategy, we found that the CHCl3 extract of the roots of Securidaca longepedunculata (Polygalaceae), collected at Democratic Republic of Congo, killed PANC-1 human pancreatic cancer cells preferentially in nutrient-deprived medium (NDM). Phytochemical investigation on the CHCl 3 extract led to the isolation of 28 compounds including five new polymethoxylated xanthones [1,6,8-trihydroxy-2,3,4,5-tetramethoxyxanthone (1), 1,6-dihydroxy-2,3,4,5,8-pentamethoxyxanthone (2), 8-hydroxy-1,4,5,6- tetramethoxy-2,3-methylenedioxyxanthone (3), 4,6,8-trihydroxy-1,2,3,5- tetramethoxyxanthone (4), 4,8-dihydroxy-1,2,3,5,6-pentamethoxyxanthone (5)] and a new benzyl benzoate [benzyl 3-hydroxy-2-methoxybenzoate (6)]. Among them, 1,6,8-trihydroxy-2,3,4,5-tetramethoxyxanthone (1) and 1,6-dihydroxy-2,3,4,5,8- pentamethoxyxanthone (2) displayed the potent preferential cytotoxicity with PC50 of 22.8 and 17.4 μM, respectively. They triggered apoptosis-like PANC-1 cell death in NDM with a glucose-sensitive mode.
AB - In a course of our search for anticancer agent based on a novel anti-austerity strategy, we found that the CHCl3 extract of the roots of Securidaca longepedunculata (Polygalaceae), collected at Democratic Republic of Congo, killed PANC-1 human pancreatic cancer cells preferentially in nutrient-deprived medium (NDM). Phytochemical investigation on the CHCl 3 extract led to the isolation of 28 compounds including five new polymethoxylated xanthones [1,6,8-trihydroxy-2,3,4,5-tetramethoxyxanthone (1), 1,6-dihydroxy-2,3,4,5,8-pentamethoxyxanthone (2), 8-hydroxy-1,4,5,6- tetramethoxy-2,3-methylenedioxyxanthone (3), 4,6,8-trihydroxy-1,2,3,5- tetramethoxyxanthone (4), 4,8-dihydroxy-1,2,3,5,6-pentamethoxyxanthone (5)] and a new benzyl benzoate [benzyl 3-hydroxy-2-methoxybenzoate (6)]. Among them, 1,6,8-trihydroxy-2,3,4,5-tetramethoxyxanthone (1) and 1,6-dihydroxy-2,3,4,5,8- pentamethoxyxanthone (2) displayed the potent preferential cytotoxicity with PC50 of 22.8 and 17.4 μM, respectively. They triggered apoptosis-like PANC-1 cell death in NDM with a glucose-sensitive mode.
KW - Congolese medicinal plant
KW - Pancreatic cancer
KW - Preferential cytotoxicity
KW - Securidaca longepedunculata
KW - Xanthone
UR - http://www.scopus.com/inward/record.url?scp=84888439935&partnerID=8YFLogxK
U2 - 10.1016/j.bmc.2013.10.027
DO - 10.1016/j.bmc.2013.10.027
M3 - 学術論文
C2 - 24216090
AN - SCOPUS:84888439935
SN - 0968-0896
VL - 21
SP - 7663
EP - 7668
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
IS - 24
ER -
