Dinorcassane Diterpenoid from Boesenbergia rotunda Rhizomes Collected in Lower Myanmar

Nwet Nwet Win; May Mon Kyaw; Prema; Hla Ngwe; Takuya Ito; Yoshinori Asakawa; Yasuko Okamoto; Masami Tanaka; Ikuro Abe; Hiroyuki Morita

doi:10.1002/cbdv.201800657

Dinorcassane Diterpenoid from Boesenbergia rotunda Rhizomes Collected in Lower Myanmar

Nwet Nwet Win^*, May Mon Kyaw, Prema, Hla Ngwe, Takuya Ito, Yoshinori Asakawa, Yasuko Okamoto, Masami Tanaka, Ikuro Abe, Hiroyuki Morita

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A new dinorcassane diterpenoid, seikphoochinal A (1), and four known compounds, pinostrobin (2), 4′,7-dimethylkaempferol (3), and galanals A (4) and B (5), were isolated from the chloroform-soluble crude extract of wild type Boesenbergia rotunda rhizomes collected in Lower Myanmar. The chemical structures of these compounds were identified, using a combination of spectroscopic methods. The presence of the diterpenoids 1, 4, and 5 demonstrated the structural diversity of wild type B. rotunda. Among the isolates, compounds 4 and 5 exhibited significant antiproliferative activities against a small panel of human cancer cell lines, including lung (LK-2, A549), stomach (ECC4), breast (MCF7), cervix (HeLa), and prostate (DU145).

Original language	English
Article number	e1800657
Journal	Chemistry and Biodiversity
Volume	16
Issue number	4
DOIs	https://doi.org/10.1002/cbdv.201800657
State	Published - 2019/04

Keywords

Boesenbergia rotunda
antiproliferative activity
biological activity
dinorcassane diterpenoid
phytochemistry
seikphoochinal A

ASJC Scopus subject areas

Bioengineering
Biochemistry
General Chemistry
Molecular Medicine
Molecular Biology

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title = "Dinorcassane Diterpenoid from Boesenbergia rotunda Rhizomes Collected in Lower Myanmar",

abstract = "A new dinorcassane diterpenoid, seikphoochinal A (1), and four known compounds, pinostrobin (2), 4′,7-dimethylkaempferol (3), and galanals A (4) and B (5), were isolated from the chloroform-soluble crude extract of wild type Boesenbergia rotunda rhizomes collected in Lower Myanmar. The chemical structures of these compounds were identified, using a combination of spectroscopic methods. The presence of the diterpenoids 1, 4, and 5 demonstrated the structural diversity of wild type B. rotunda. Among the isolates, compounds 4 and 5 exhibited significant antiproliferative activities against a small panel of human cancer cell lines, including lung (LK-2, A549), stomach (ECC4), breast (MCF7), cervix (HeLa), and prostate (DU145).",

keywords = "Boesenbergia rotunda, antiproliferative activity, biological activity, dinorcassane diterpenoid, phytochemistry, seikphoochinal A",

author = "Win, {Nwet Nwet} and Kyaw, {May Mon} and Prema and Hla Ngwe and Takuya Ito and Yoshinori Asakawa and Yasuko Okamoto and Masami Tanaka and Ikuro Abe and Hiroyuki Morita",

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year = "2019",

month = apr,

doi = "10.1002/cbdv.201800657",

language = "英語",

volume = "16",

journal = "Chemistry and Biodiversity",

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T1 - Dinorcassane Diterpenoid from Boesenbergia rotunda Rhizomes Collected in Lower Myanmar

AU - Win, Nwet Nwet

AU - Kyaw, May Mon

AU - Prema,

AU - Ngwe, Hla

AU - Ito, Takuya

AU - Asakawa, Yoshinori

AU - Okamoto, Yasuko

AU - Tanaka, Masami

AU - Abe, Ikuro

AU - Morita, Hiroyuki

PY - 2019/4

Y1 - 2019/4

N2 - A new dinorcassane diterpenoid, seikphoochinal A (1), and four known compounds, pinostrobin (2), 4′,7-dimethylkaempferol (3), and galanals A (4) and B (5), were isolated from the chloroform-soluble crude extract of wild type Boesenbergia rotunda rhizomes collected in Lower Myanmar. The chemical structures of these compounds were identified, using a combination of spectroscopic methods. The presence of the diterpenoids 1, 4, and 5 demonstrated the structural diversity of wild type B. rotunda. Among the isolates, compounds 4 and 5 exhibited significant antiproliferative activities against a small panel of human cancer cell lines, including lung (LK-2, A549), stomach (ECC4), breast (MCF7), cervix (HeLa), and prostate (DU145).

AB - A new dinorcassane diterpenoid, seikphoochinal A (1), and four known compounds, pinostrobin (2), 4′,7-dimethylkaempferol (3), and galanals A (4) and B (5), were isolated from the chloroform-soluble crude extract of wild type Boesenbergia rotunda rhizomes collected in Lower Myanmar. The chemical structures of these compounds were identified, using a combination of spectroscopic methods. The presence of the diterpenoids 1, 4, and 5 demonstrated the structural diversity of wild type B. rotunda. Among the isolates, compounds 4 and 5 exhibited significant antiproliferative activities against a small panel of human cancer cell lines, including lung (LK-2, A549), stomach (ECC4), breast (MCF7), cervix (HeLa), and prostate (DU145).

KW - Boesenbergia rotunda

KW - antiproliferative activity

KW - biological activity

KW - dinorcassane diterpenoid

KW - phytochemistry

KW - seikphoochinal A

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U2 - 10.1002/cbdv.201800657

DO - 10.1002/cbdv.201800657

M3 - 学術論文

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AN - SCOPUS:85063187441

SN - 1612-1872

VL - 16

JO - Chemistry and Biodiversity

JF - Chemistry and Biodiversity

IS - 4

M1 - e1800657

ER -

Dinorcassane Diterpenoid from Boesenbergia rotunda Rhizomes Collected in Lower Myanmar

Abstract

Keywords

ASJC Scopus subject areas

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