Dinorcassane Diterpenoid from Boesenbergia rotunda Rhizomes Collected in Lower Myanmar

Nwet Nwet Win; May Mon Kyaw; Prema; Hla Ngwe; Takuya Ito; Yoshinori Asakawa; Yasuko Okamoto; Masami Tanaka; Ikuro Abe; Hiroyuki Morita

doi:10.1002/cbdv.201800657

Dinorcassane Diterpenoid from Boesenbergia rotunda Rhizomes Collected in Lower Myanmar

Nwet Nwet Win^*, May Mon Kyaw, Prema, Hla Ngwe, Takuya Ito, Yoshinori Asakawa, Yasuko Okamoto, Masami Tanaka, Ikuro Abe, Hiroyuki Morita

^*この論文の責任著者

和漢医薬学総合研究所研究開発部門資源開発分野（天然物創薬学領域）

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

7 被引用数 (Scopus)

抄録

A new dinorcassane diterpenoid, seikphoochinal A (1), and four known compounds, pinostrobin (2), 4′,7-dimethylkaempferol (3), and galanals A (4) and B (5), were isolated from the chloroform-soluble crude extract of wild type Boesenbergia rotunda rhizomes collected in Lower Myanmar. The chemical structures of these compounds were identified, using a combination of spectroscopic methods. The presence of the diterpenoids 1, 4, and 5 demonstrated the structural diversity of wild type B. rotunda. Among the isolates, compounds 4 and 5 exhibited significant antiproliferative activities against a small panel of human cancer cell lines, including lung (LK-2, A549), stomach (ECC4), breast (MCF7), cervix (HeLa), and prostate (DU145).

本文言語	英語
論文番号	e1800657
ジャーナル	Chemistry and Biodiversity
巻	16
号	4
DOI	https://doi.org/10.1002/cbdv.201800657
出版ステータス	出版済み - 2019/04

ASJC Scopus 主題領域

バイオエンジニアリング
生化学
化学一般
分子医療
分子生物学

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10.1002/cbdv.201800657

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title = "Dinorcassane Diterpenoid from Boesenbergia rotunda Rhizomes Collected in Lower Myanmar",

abstract = "A new dinorcassane diterpenoid, seikphoochinal A (1), and four known compounds, pinostrobin (2), 4′,7-dimethylkaempferol (3), and galanals A (4) and B (5), were isolated from the chloroform-soluble crude extract of wild type Boesenbergia rotunda rhizomes collected in Lower Myanmar. The chemical structures of these compounds were identified, using a combination of spectroscopic methods. The presence of the diterpenoids 1, 4, and 5 demonstrated the structural diversity of wild type B. rotunda. Among the isolates, compounds 4 and 5 exhibited significant antiproliferative activities against a small panel of human cancer cell lines, including lung (LK-2, A549), stomach (ECC4), breast (MCF7), cervix (HeLa), and prostate (DU145).",

keywords = "Boesenbergia rotunda, antiproliferative activity, biological activity, dinorcassane diterpenoid, phytochemistry, seikphoochinal A",

author = "Win, {Nwet Nwet} and Kyaw, {May Mon} and Prema and Hla Ngwe and Takuya Ito and Yoshinori Asakawa and Yasuko Okamoto and Masami Tanaka and Ikuro Abe and Hiroyuki Morita",

note = "Publisher Copyright: {\textcopyright} 2019 Wiley-VHCA AG, Zurich, Switzerland",

year = "2019",

month = apr,

doi = "10.1002/cbdv.201800657",

language = "英語",

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T1 - Dinorcassane Diterpenoid from Boesenbergia rotunda Rhizomes Collected in Lower Myanmar

AU - Win, Nwet Nwet

AU - Kyaw, May Mon

AU - Prema,

AU - Ngwe, Hla

AU - Ito, Takuya

AU - Asakawa, Yoshinori

AU - Okamoto, Yasuko

AU - Tanaka, Masami

AU - Abe, Ikuro

AU - Morita, Hiroyuki

PY - 2019/4

Y1 - 2019/4

N2 - A new dinorcassane diterpenoid, seikphoochinal A (1), and four known compounds, pinostrobin (2), 4′,7-dimethylkaempferol (3), and galanals A (4) and B (5), were isolated from the chloroform-soluble crude extract of wild type Boesenbergia rotunda rhizomes collected in Lower Myanmar. The chemical structures of these compounds were identified, using a combination of spectroscopic methods. The presence of the diterpenoids 1, 4, and 5 demonstrated the structural diversity of wild type B. rotunda. Among the isolates, compounds 4 and 5 exhibited significant antiproliferative activities against a small panel of human cancer cell lines, including lung (LK-2, A549), stomach (ECC4), breast (MCF7), cervix (HeLa), and prostate (DU145).

AB - A new dinorcassane diterpenoid, seikphoochinal A (1), and four known compounds, pinostrobin (2), 4′,7-dimethylkaempferol (3), and galanals A (4) and B (5), were isolated from the chloroform-soluble crude extract of wild type Boesenbergia rotunda rhizomes collected in Lower Myanmar. The chemical structures of these compounds were identified, using a combination of spectroscopic methods. The presence of the diterpenoids 1, 4, and 5 demonstrated the structural diversity of wild type B. rotunda. Among the isolates, compounds 4 and 5 exhibited significant antiproliferative activities against a small panel of human cancer cell lines, including lung (LK-2, A549), stomach (ECC4), breast (MCF7), cervix (HeLa), and prostate (DU145).

KW - Boesenbergia rotunda

KW - antiproliferative activity

KW - biological activity

KW - dinorcassane diterpenoid

KW - phytochemistry

KW - seikphoochinal A

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U2 - 10.1002/cbdv.201800657

DO - 10.1002/cbdv.201800657

M3 - 学術論文

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AN - SCOPUS:85063187441

SN - 1612-1872

VL - 16

JO - Chemistry and Biodiversity

JF - Chemistry and Biodiversity

IS - 4

M1 - e1800657

ER -

Dinorcassane Diterpenoid from Boesenbergia rotunda Rhizomes Collected in Lower Myanmar

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