Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and β cell glucokinase genes: Genetic reconstitution of diabetes as a polygenic disease

Yasuo Terauchi, Keiji Iwamoto, Hiroyuki Tamemoto, Kajuro Komeda, Chikara Ishii, Yasunori Kanazawa, Nahoko Asanuma, Toru Aizawa, Yasuo Akanuma, Kazuki Yasuda, Tatsuhiko Kodama, Kazuyuki Tobe, Yoshio Yazaki, Takashi Kadowaki*

*Corresponding author for this work

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Biochemistry, Genetics and Molecular Biology