Design, synthesis, and biological effect of (1-oxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)-acetic acids as inhibitor of aldose reductase 2

Naoki Toyooka; Daisuke Takeda; Yuka Minoshima; Atsushi Kato; Isao Adachi

doi:10.3987/COM-08-S(D)17

Design, synthesis, and biological effect of (1-oxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)-acetic acids as inhibitor of aldose reductase 2

Naoki Toyooka^*, Daisuke Takeda, Yuka Minoshima, Atsushi Kato, Isao Adachi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Design and synthesis of (1-oxo-l,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acids (4a-e) have been described. The acids (4a-e) synthesized here showed good to moderate inhibitory effects (IC₅₀ = 21.7 ~ 45.3 μM) for the aldose reductase 2 (ALR2).

Original language	English
Pages (from-to)	1073-1080
Number of pages	8
Journal	Heterocycles
Volume	79
Issue number	C
DOIs	https://doi.org/10.3987/COM-08-S(D)17
State	Published - 2009

Keywords

1-Oxo-1,2,3,4-tetrahydro-β-carbolin-9-ylacetic Acid
Aldehyde Dehydrogenase
Aldose Reductase 2
Polyol Pathway
Rhetsinine

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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title = "Design, synthesis, and biological effect of (1-oxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)-acetic acids as inhibitor of aldose reductase 2",

abstract = "Design and synthesis of (1-oxo-l,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acids (4a-e) have been described. The acids (4a-e) synthesized here showed good to moderate inhibitory effects (IC50 = 21.7 ~ 45.3 μM) for the aldose reductase 2 (ALR2).",

keywords = "1-Oxo-1,2,3,4-tetrahydro-β-carbolin-9-ylacetic Acid, Aldehyde Dehydrogenase, Aldose Reductase 2, Polyol Pathway, Rhetsinine",

author = "Naoki Toyooka and Daisuke Takeda and Yuka Minoshima and Atsushi Kato and Isao Adachi",

year = "2009",

doi = "10.3987/COM-08-S(D)17",

language = "英語",

volume = "79",

pages = "1073--1080",

journal = "Heterocycles",

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publisher = "Japan Institute of Heterocyclic Chemistry",

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TY - JOUR

T1 - Design, synthesis, and biological effect of (1-oxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)-acetic acids as inhibitor of aldose reductase 2

AU - Toyooka, Naoki

AU - Takeda, Daisuke

AU - Minoshima, Yuka

AU - Kato, Atsushi

AU - Adachi, Isao

PY - 2009

Y1 - 2009

N2 - Design and synthesis of (1-oxo-l,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acids (4a-e) have been described. The acids (4a-e) synthesized here showed good to moderate inhibitory effects (IC50 = 21.7 ~ 45.3 μM) for the aldose reductase 2 (ALR2).

AB - Design and synthesis of (1-oxo-l,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acids (4a-e) have been described. The acids (4a-e) synthesized here showed good to moderate inhibitory effects (IC50 = 21.7 ~ 45.3 μM) for the aldose reductase 2 (ALR2).

KW - 1-Oxo-1,2,3,4-tetrahydro-β-carbolin-9-ylacetic Acid

KW - Aldehyde Dehydrogenase

KW - Aldose Reductase 2

KW - Polyol Pathway

KW - Rhetsinine

UR - http://www.scopus.com/inward/record.url?scp=67651087392&partnerID=8YFLogxK

U2 - 10.3987/COM-08-S(D)17

DO - 10.3987/COM-08-S(D)17

M3 - 学術論文

AN - SCOPUS:67651087392

SN - 0385-5414

VL - 79

SP - 1073

EP - 1080

JO - Heterocycles

JF - Heterocycles

IS - C

ER -

Design, synthesis, and biological effect of (1-oxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)-acetic acids as inhibitor of aldose reductase 2

Abstract

Keywords

ASJC Scopus subject areas

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