Clinical implication of recent advances in our understanding of IL-17 and reproductive immunology

Shigeru Saito; Akitoshi Nakashima; Mika Ito; Tomoko Shima

doi:10.1586/eci.11.49

Clinical implication of recent advances in our understanding of IL-17 and reproductive immunology

Shigeru Saito^*, Akitoshi Nakashima, Mika Ito, Tomoko Shima

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

68 Scopus citations

Abstract

The identification of a novel helper T (Th)-cell subset, the IL-17-producing Th (Th17) cells, has provided new insight into our understanding of the molecular mechanisms of reproduction. IL-17 has an important role in induction of the protective immune response against extracellular bacteria or fungal pathogens. Th17 cells seem to participate in successful pregnancy processes. Th17 cells also play a pivotal role in pathogenesis of endometriosis, miscarriage, preterm labor and preeclampsia. Recent data show the reciprocal development of pathways between Th1/Th17 subsets and between Th17/Treg subsets, and the imbalance of Th17/Treg development has been reported in recurrent pregnancy loss and preeclampsia.

Original language	English
Pages (from-to)	649-657
Number of pages	9
Journal	Expert Review of Clinical Immunology
Volume	7
Issue number	5
DOIs	https://doi.org/10.1586/eci.11.49
State	Published - 2011/09

Keywords

IL-17
abortion
endometriosis
pregnancy
preterm labor

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1586/eci.11.49

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title = "Clinical implication of recent advances in our understanding of IL-17 and reproductive immunology",

abstract = "The identification of a novel helper T (Th)-cell subset, the IL-17-producing Th (Th17) cells, has provided new insight into our understanding of the molecular mechanisms of reproduction. IL-17 has an important role in induction of the protective immune response against extracellular bacteria or fungal pathogens. Th17 cells seem to participate in successful pregnancy processes. Th17 cells also play a pivotal role in pathogenesis of endometriosis, miscarriage, preterm labor and preeclampsia. Recent data show the reciprocal development of pathways between Th1/Th17 subsets and between Th17/Treg subsets, and the imbalance of Th17/Treg development has been reported in recurrent pregnancy loss and preeclampsia.",

keywords = "IL-17, abortion, endometriosis, pregnancy, preterm labor",

author = "Shigeru Saito and Akitoshi Nakashima and Mika Ito and Tomoko Shima",

note = "Funding Information: This work was supported by a grant from the Ministry of Education, Culture, Sports, Science and Technology, Japan (Grant-in-Aid for Scientific Research (B)-23390386) and Grant-in-Aid for challenging Exploratory Research-22659297) and grants from the Ministry of Health Labour and Welfare, Japan (Health Labour Sciences Research Grant – H22-jisedai-ippan-008, H22-nanchi-ippan-159, H22-kagaku-ippan-006, H22-rinkensui-ippan-013, H23-shinkou-ippan-016 and H23-jisedai-shitei-008). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.",

year = "2011",

month = sep,

doi = "10.1586/eci.11.49",

language = "英語",

volume = "7",

pages = "649--657",

journal = "Expert Review of Clinical Immunology",

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AU - Saito, Shigeru

AU - Nakashima, Akitoshi

AU - Ito, Mika

AU - Shima, Tomoko

N1 - Funding Information: This work was supported by a grant from the Ministry of Education, Culture, Sports, Science and Technology, Japan (Grant-in-Aid for Scientific Research (B)-23390386) and Grant-in-Aid for challenging Exploratory Research-22659297) and grants from the Ministry of Health Labour and Welfare, Japan (Health Labour Sciences Research Grant – H22-jisedai-ippan-008, H22-nanchi-ippan-159, H22-kagaku-ippan-006, H22-rinkensui-ippan-013, H23-shinkou-ippan-016 and H23-jisedai-shitei-008). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

PY - 2011/9

Y1 - 2011/9

N2 - The identification of a novel helper T (Th)-cell subset, the IL-17-producing Th (Th17) cells, has provided new insight into our understanding of the molecular mechanisms of reproduction. IL-17 has an important role in induction of the protective immune response against extracellular bacteria or fungal pathogens. Th17 cells seem to participate in successful pregnancy processes. Th17 cells also play a pivotal role in pathogenesis of endometriosis, miscarriage, preterm labor and preeclampsia. Recent data show the reciprocal development of pathways between Th1/Th17 subsets and between Th17/Treg subsets, and the imbalance of Th17/Treg development has been reported in recurrent pregnancy loss and preeclampsia.

AB - The identification of a novel helper T (Th)-cell subset, the IL-17-producing Th (Th17) cells, has provided new insight into our understanding of the molecular mechanisms of reproduction. IL-17 has an important role in induction of the protective immune response against extracellular bacteria or fungal pathogens. Th17 cells seem to participate in successful pregnancy processes. Th17 cells also play a pivotal role in pathogenesis of endometriosis, miscarriage, preterm labor and preeclampsia. Recent data show the reciprocal development of pathways between Th1/Th17 subsets and between Th17/Treg subsets, and the imbalance of Th17/Treg development has been reported in recurrent pregnancy loss and preeclampsia.

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Clinical implication of recent advances in our understanding of IL-17 and reproductive immunology

Abstract

Keywords

ASJC Scopus subject areas

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