@article{05026a2614b94dea84c5172a89cebd71,
title = "Clinical implication of recent advances in our understanding of IL-17 and reproductive immunology",
abstract = "The identification of a novel helper T (Th)-cell subset, the IL-17-producing Th (Th17) cells, has provided new insight into our understanding of the molecular mechanisms of reproduction. IL-17 has an important role in induction of the protective immune response against extracellular bacteria or fungal pathogens. Th17 cells seem to participate in successful pregnancy processes. Th17 cells also play a pivotal role in pathogenesis of endometriosis, miscarriage, preterm labor and preeclampsia. Recent data show the reciprocal development of pathways between Th1/Th17 subsets and between Th17/Treg subsets, and the imbalance of Th17/Treg development has been reported in recurrent pregnancy loss and preeclampsia.",
keywords = "IL-17, abortion, endometriosis, pregnancy, preterm labor",
author = "Shigeru Saito and Akitoshi Nakashima and Mika Ito and Tomoko Shima",
note = "Funding Information: This work was supported by a grant from the Ministry of Education, Culture, Sports, Science and Technology, Japan (Grant-in-Aid for Scientific Research (B)-23390386) and Grant-in-Aid for challenging Exploratory Research-22659297) and grants from the Ministry of Health Labour and Welfare, Japan (Health Labour Sciences Research Grant – H22-jisedai-ippan-008, H22-nanchi-ippan-159, H22-kagaku-ippan-006, H22-rinkensui-ippan-013, H23-shinkou-ippan-016 and H23-jisedai-shitei-008). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.",
year = "2011",
month = sep,
doi = "10.1586/eci.11.49",
language = "英語",
volume = "7",
pages = "649--657",
journal = "Expert Review of Clinical Immunology",
issn = "1744-666X",
publisher = "Taylor and Francis Ltd.",
number = "5",
}