Chiro-Inositol Derivatives from Chisocheton paniculatus Showing Inhibition of Nitric Oxide Production

Khan Viet Nguyen; Duc Viet Ho; Hien Minh Nguyen; Thao Thi Do; Kiem Van Phan; Hiroyuki Morita; Jyrki Heinämäki; Ain Raal; Hoai Thi Nguyen

doi:10.1021/acs.jnatprod.9b01239

Chiro-Inositol Derivatives from Chisocheton paniculatus Showing Inhibition of Nitric Oxide Production

Khan Viet Nguyen, Duc Viet Ho, Hien Minh Nguyen, Thao Thi Do, Kiem Van Phan, Hiroyuki Morita, Jyrki Heinämäki, Ain Raal^*, Hoai Thi Nguyen

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Six new chiro-inositol derivatives (1-6) were isolated from the leaves of Chisocheton paniculatus collected in Vietnam. Their chemical structures were elucidated by 1D and 2D NMR and HRESIMS analyses. All isolated compounds were evaluated for their inhibitory activity against lipopolysaccharide-induced nitric oxide (NO) production in the RAW 264.7 macrophage cell line. Compound 4 exhibited potent inhibitory activity for NO production with an IC₅₀ value of 7.1 μM.

Original language	English
Pages (from-to)	1201-1206
Number of pages	6
Journal	Journal of Natural Products
Volume	83
Issue number	4
DOIs	https://doi.org/10.1021/acs.jnatprod.9b01239
State	Published - 2020/04/24

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Chiro-Inositol Derivatives from Chisocheton paniculatus Showing Inhibition of Nitric Oxide Production",

abstract = "Six new chiro-inositol derivatives (1-6) were isolated from the leaves of Chisocheton paniculatus collected in Vietnam. Their chemical structures were elucidated by 1D and 2D NMR and HRESIMS analyses. All isolated compounds were evaluated for their inhibitory activity against lipopolysaccharide-induced nitric oxide (NO) production in the RAW 264.7 macrophage cell line. Compound 4 exhibited potent inhibitory activity for NO production with an IC50 value of 7.1 μM.",

author = "Nguyen, {Khan Viet} and Ho, {Duc Viet} and Nguyen, {Hien Minh} and Do, {Thao Thi} and Phan, {Kiem Van} and Hiroyuki Morita and Jyrki Hein{\"a}m{\"a}ki and Ain Raal and Nguyen, {Hoai Thi}",

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AU - Nguyen, Khan Viet

AU - Ho, Duc Viet

AU - Nguyen, Hien Minh

AU - Do, Thao Thi

AU - Phan, Kiem Van

AU - Morita, Hiroyuki

AU - Heinämäki, Jyrki

AU - Raal, Ain

AU - Nguyen, Hoai Thi

PY - 2020/4/24

Y1 - 2020/4/24

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AB - Six new chiro-inositol derivatives (1-6) were isolated from the leaves of Chisocheton paniculatus collected in Vietnam. Their chemical structures were elucidated by 1D and 2D NMR and HRESIMS analyses. All isolated compounds were evaluated for their inhibitory activity against lipopolysaccharide-induced nitric oxide (NO) production in the RAW 264.7 macrophage cell line. Compound 4 exhibited potent inhibitory activity for NO production with an IC50 value of 7.1 μM.

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JF - Journal of Natural Products

IS - 4

ER -

Chiro-Inositol Derivatives from Chisocheton paniculatus Showing Inhibition of Nitric Oxide Production

Abstract

ASJC Scopus subject areas

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