Chiro-Inositol Derivatives from Chisocheton paniculatus Showing Inhibition of Nitric Oxide Production

Khan Viet Nguyen; Duc Viet Ho; Hien Minh Nguyen; Thao Thi Do; Kiem Van Phan; Hiroyuki Morita; Jyrki Heinämäki; Ain Raal; Hoai Thi Nguyen

doi:10.1021/acs.jnatprod.9b01239

Chiro-Inositol Derivatives from Chisocheton paniculatus Showing Inhibition of Nitric Oxide Production

Khan Viet Nguyen, Duc Viet Ho, Hien Minh Nguyen, Thao Thi Do, Kiem Van Phan, Hiroyuki Morita, Jyrki Heinämäki, Ain Raal^*, Hoai Thi Nguyen

^*この論文の責任著者

和漢医薬学総合研究所研究開発部門資源開発分野（天然物創薬学領域）

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

13 被引用数 (Scopus)

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Six new chiro-inositol derivatives (1-6) were isolated from the leaves of Chisocheton paniculatus collected in Vietnam. Their chemical structures were elucidated by 1D and 2D NMR and HRESIMS analyses. All isolated compounds were evaluated for their inhibitory activity against lipopolysaccharide-induced nitric oxide (NO) production in the RAW 264.7 macrophage cell line. Compound 4 exhibited potent inhibitory activity for NO production with an IC₅₀ value of 7.1 μM.

本文言語	英語
ページ（範囲）	1201-1206
ページ数	6
ジャーナル	Journal of Natural Products
巻	83
号	4
DOI	https://doi.org/10.1021/acs.jnatprod.9b01239
出版ステータス	出版済み - 2020/04/24

ASJC Scopus 主題領域

分析化学
分子医療
薬理学
薬科学
創薬
補完代替医療
有機化学

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10.1021/acs.jnatprod.9b01239

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title = "Chiro-Inositol Derivatives from Chisocheton paniculatus Showing Inhibition of Nitric Oxide Production",

abstract = "Six new chiro-inositol derivatives (1-6) were isolated from the leaves of Chisocheton paniculatus collected in Vietnam. Their chemical structures were elucidated by 1D and 2D NMR and HRESIMS analyses. All isolated compounds were evaluated for their inhibitory activity against lipopolysaccharide-induced nitric oxide (NO) production in the RAW 264.7 macrophage cell line. Compound 4 exhibited potent inhibitory activity for NO production with an IC50 value of 7.1 μM.",

author = "Nguyen, {Khan Viet} and Ho, {Duc Viet} and Nguyen, {Hien Minh} and Do, {Thao Thi} and Phan, {Kiem Van} and Hiroyuki Morita and Jyrki Hein{\"a}m{\"a}ki and Ain Raal and Nguyen, {Hoai Thi}",

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day = "24",

doi = "10.1021/acs.jnatprod.9b01239",

language = "英語",

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T1 - Chiro-Inositol Derivatives from Chisocheton paniculatus Showing Inhibition of Nitric Oxide Production

AU - Nguyen, Khan Viet

AU - Ho, Duc Viet

AU - Nguyen, Hien Minh

AU - Do, Thao Thi

AU - Phan, Kiem Van

AU - Morita, Hiroyuki

AU - Heinämäki, Jyrki

AU - Raal, Ain

AU - Nguyen, Hoai Thi

PY - 2020/4/24

Y1 - 2020/4/24

N2 - Six new chiro-inositol derivatives (1-6) were isolated from the leaves of Chisocheton paniculatus collected in Vietnam. Their chemical structures were elucidated by 1D and 2D NMR and HRESIMS analyses. All isolated compounds were evaluated for their inhibitory activity against lipopolysaccharide-induced nitric oxide (NO) production in the RAW 264.7 macrophage cell line. Compound 4 exhibited potent inhibitory activity for NO production with an IC50 value of 7.1 μM.

AB - Six new chiro-inositol derivatives (1-6) were isolated from the leaves of Chisocheton paniculatus collected in Vietnam. Their chemical structures were elucidated by 1D and 2D NMR and HRESIMS analyses. All isolated compounds were evaluated for their inhibitory activity against lipopolysaccharide-induced nitric oxide (NO) production in the RAW 264.7 macrophage cell line. Compound 4 exhibited potent inhibitory activity for NO production with an IC50 value of 7.1 μM.

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U2 - 10.1021/acs.jnatprod.9b01239

DO - 10.1021/acs.jnatprod.9b01239

M3 - 学術論文

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AN - SCOPUS:85082510689

SN - 0163-3864

VL - 83

SP - 1201

EP - 1206

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 4

ER -

Chiro-Inositol Derivatives from Chisocheton paniculatus Showing Inhibition of Nitric Oxide Production

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