Catenulobactins A and B, Heterocyclic Peptides from Culturing Catenuloplanes sp. with a Mycolic Acid-Containing Bacterium

Shotaro Hoshino; Masahiro Ozeki; Takayoshi Awakawa; Hiroyuki Morita; Hiroyasu Onaka; Ikuro Abe

doi:10.1021/acs.jnatprod.8b00261

Catenulobactins A and B, Heterocyclic Peptides from Culturing Catenuloplanes sp. with a Mycolic Acid-Containing Bacterium

Shotaro Hoshino, Masahiro Ozeki, Takayoshi Awakawa, Hiroyuki Morita, Hiroyasu Onaka, Ikuro Abe^*

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

The production of two new heterocyclic peptide isomers, catenulobactins A (1) and B (2), in cultures of Catenuloplanes sp. RD067331 was significantly increased when it was cocultured with a mycolic acid-containing bacterium. The planar structures and absolute configurations of the catenulobactins were determined based on NMR/MS and chiral-phase GC-MS analyses. Catenulobactin B (2) displayed Fe(III)-chelating activity and moderate cytotoxicity against P388 murine leukemia cells.

Original language	English
Pages (from-to)	2106-2110
Number of pages	5
Journal	Journal of Natural Products
Volume	81
Issue number	9
DOIs	https://doi.org/10.1021/acs.jnatprod.8b00261
State	Published - 2018/09/28

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Catenulobactins A and B, Heterocyclic Peptides from Culturing Catenuloplanes sp. with a Mycolic Acid-Containing Bacterium",

abstract = "The production of two new heterocyclic peptide isomers, catenulobactins A (1) and B (2), in cultures of Catenuloplanes sp. RD067331 was significantly increased when it was cocultured with a mycolic acid-containing bacterium. The planar structures and absolute configurations of the catenulobactins were determined based on NMR/MS and chiral-phase GC-MS analyses. Catenulobactin B (2) displayed Fe(III)-chelating activity and moderate cytotoxicity against P388 murine leukemia cells.",

author = "Shotaro Hoshino and Masahiro Ozeki and Takayoshi Awakawa and Hiroyuki Morita and Hiroyasu Onaka and Ikuro Abe",

note = "Publisher Copyright: Copyright {\textcopyright} 2018 American Chemical Society and American Society of Pharmacognosy.",

year = "2018",

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doi = "10.1021/acs.jnatprod.8b00261",

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T1 - Catenulobactins A and B, Heterocyclic Peptides from Culturing Catenuloplanes sp. with a Mycolic Acid-Containing Bacterium

AU - Hoshino, Shotaro

AU - Ozeki, Masahiro

AU - Awakawa, Takayoshi

AU - Morita, Hiroyuki

AU - Onaka, Hiroyasu

AU - Abe, Ikuro

PY - 2018/9/28

Y1 - 2018/9/28

N2 - The production of two new heterocyclic peptide isomers, catenulobactins A (1) and B (2), in cultures of Catenuloplanes sp. RD067331 was significantly increased when it was cocultured with a mycolic acid-containing bacterium. The planar structures and absolute configurations of the catenulobactins were determined based on NMR/MS and chiral-phase GC-MS analyses. Catenulobactin B (2) displayed Fe(III)-chelating activity and moderate cytotoxicity against P388 murine leukemia cells.

AB - The production of two new heterocyclic peptide isomers, catenulobactins A (1) and B (2), in cultures of Catenuloplanes sp. RD067331 was significantly increased when it was cocultured with a mycolic acid-containing bacterium. The planar structures and absolute configurations of the catenulobactins were determined based on NMR/MS and chiral-phase GC-MS analyses. Catenulobactin B (2) displayed Fe(III)-chelating activity and moderate cytotoxicity against P388 murine leukemia cells.

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SN - 0163-3864

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JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 9

ER -

Catenulobactins A and B, Heterocyclic Peptides from Culturing Catenuloplanes sp. with a Mycolic Acid-Containing Bacterium

Abstract

ASJC Scopus subject areas

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