Catenulobactins A and B, Heterocyclic Peptides from Culturing Catenuloplanes sp. with a Mycolic Acid-Containing Bacterium

Shotaro Hoshino; Masahiro Ozeki; Takayoshi Awakawa; Hiroyuki Morita; Hiroyasu Onaka; Ikuro Abe

doi:10.1021/acs.jnatprod.8b00261

Catenulobactins A and B, Heterocyclic Peptides from Culturing Catenuloplanes sp. with a Mycolic Acid-Containing Bacterium

Shotaro Hoshino, Masahiro Ozeki, Takayoshi Awakawa, Hiroyuki Morita, Hiroyasu Onaka, Ikuro Abe^*

^*この論文の責任著者

和漢医薬学総合研究所研究開発部門資源開発分野（天然物創薬学領域）

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

28 被引用数 (Scopus)

抄録

The production of two new heterocyclic peptide isomers, catenulobactins A (1) and B (2), in cultures of Catenuloplanes sp. RD067331 was significantly increased when it was cocultured with a mycolic acid-containing bacterium. The planar structures and absolute configurations of the catenulobactins were determined based on NMR/MS and chiral-phase GC-MS analyses. Catenulobactin B (2) displayed Fe(III)-chelating activity and moderate cytotoxicity against P388 murine leukemia cells.

本文言語	英語
ページ（範囲）	2106-2110
ページ数	5
ジャーナル	Journal of Natural Products
巻	81
号	9
DOI	https://doi.org/10.1021/acs.jnatprod.8b00261
出版ステータス	出版済み - 2018/09/28

ASJC Scopus 主題領域

分析化学
分子医療
薬理学
薬科学
創薬
補完代替医療
有機化学

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10.1021/acs.jnatprod.8b00261

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title = "Catenulobactins A and B, Heterocyclic Peptides from Culturing Catenuloplanes sp. with a Mycolic Acid-Containing Bacterium",

abstract = "The production of two new heterocyclic peptide isomers, catenulobactins A (1) and B (2), in cultures of Catenuloplanes sp. RD067331 was significantly increased when it was cocultured with a mycolic acid-containing bacterium. The planar structures and absolute configurations of the catenulobactins were determined based on NMR/MS and chiral-phase GC-MS analyses. Catenulobactin B (2) displayed Fe(III)-chelating activity and moderate cytotoxicity against P388 murine leukemia cells.",

author = "Shotaro Hoshino and Masahiro Ozeki and Takayoshi Awakawa and Hiroyuki Morita and Hiroyasu Onaka and Ikuro Abe",

note = "Publisher Copyright: Copyright {\textcopyright} 2018 American Chemical Society and American Society of Pharmacognosy.",

year = "2018",

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day = "28",

doi = "10.1021/acs.jnatprod.8b00261",

language = "英語",

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T1 - Catenulobactins A and B, Heterocyclic Peptides from Culturing Catenuloplanes sp. with a Mycolic Acid-Containing Bacterium

AU - Hoshino, Shotaro

AU - Ozeki, Masahiro

AU - Awakawa, Takayoshi

AU - Morita, Hiroyuki

AU - Onaka, Hiroyasu

AU - Abe, Ikuro

PY - 2018/9/28

Y1 - 2018/9/28

N2 - The production of two new heterocyclic peptide isomers, catenulobactins A (1) and B (2), in cultures of Catenuloplanes sp. RD067331 was significantly increased when it was cocultured with a mycolic acid-containing bacterium. The planar structures and absolute configurations of the catenulobactins were determined based on NMR/MS and chiral-phase GC-MS analyses. Catenulobactin B (2) displayed Fe(III)-chelating activity and moderate cytotoxicity against P388 murine leukemia cells.

AB - The production of two new heterocyclic peptide isomers, catenulobactins A (1) and B (2), in cultures of Catenuloplanes sp. RD067331 was significantly increased when it was cocultured with a mycolic acid-containing bacterium. The planar structures and absolute configurations of the catenulobactins were determined based on NMR/MS and chiral-phase GC-MS analyses. Catenulobactin B (2) displayed Fe(III)-chelating activity and moderate cytotoxicity against P388 murine leukemia cells.

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U2 - 10.1021/acs.jnatprod.8b00261

DO - 10.1021/acs.jnatprod.8b00261

M3 - 学術論文

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AN - SCOPUS:85052934234

SN - 0163-3864

VL - 81

SP - 2106

EP - 2110

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 9

ER -

Catenulobactins A and B, Heterocyclic Peptides from Culturing Catenuloplanes sp. with a Mycolic Acid-Containing Bacterium

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