Asymmetric synthesis of 1-alkyl-2-deoxyiminofuranoses via the iridium-catalyzed intramolecular cyclization of an allylic carbonate

Yoshihiro Natori; Shunsuke Kikuchi; Yuichi Yoshimura; Atsushi Kato; Isao Adachi; Hiroki Takahata

doi:10.3987/COM-12-S(N)99

Asymmetric synthesis of 1-alkyl-2-deoxyiminofuranoses via the iridium-catalyzed intramolecular cyclization of an allylic carbonate

Yoshihiro Natori, Shunsuke Kikuchi, Yuichi Yoshimura, Atsushi Kato, Isao Adachi, Hiroki Takahata

Hospital Pharmacy

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

An asymmetric synthesis of 1-alkyl-2-deoxyiminofuranoses was achieved in which the Ir-catalyzed intramolecular cyclization was the key step. The diastereoselective cyclization converted an allylic carbonate into pyrrolidine derivatives. The a-glucosidase inhibitory activities of the prepared 2-deoxyiminofuranoses were also investigated.

Original language	English
Pages (from-to)	1401-1417
Number of pages	17
Journal	Heterocycles
Volume	86
Issue number	2
DOIs	https://doi.org/10.3987/COM-12-S(N)99
State	Published - 2012

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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title = "Asymmetric synthesis of 1-alkyl-2-deoxyiminofuranoses via the iridium-catalyzed intramolecular cyclization of an allylic carbonate",

abstract = "An asymmetric synthesis of 1-alkyl-2-deoxyiminofuranoses was achieved in which the Ir-catalyzed intramolecular cyclization was the key step. The diastereoselective cyclization converted an allylic carbonate into pyrrolidine derivatives. The a-glucosidase inhibitory activities of the prepared 2-deoxyiminofuranoses were also investigated.",

author = "Yoshihiro Natori and Shunsuke Kikuchi and Yuichi Yoshimura and Atsushi Kato and Isao Adachi and Hiroki Takahata",

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T1 - Asymmetric synthesis of 1-alkyl-2-deoxyiminofuranoses via the iridium-catalyzed intramolecular cyclization of an allylic carbonate

AU - Natori, Yoshihiro

AU - Kikuchi, Shunsuke

AU - Yoshimura, Yuichi

AU - Kato, Atsushi

AU - Adachi, Isao

AU - Takahata, Hiroki

PY - 2012

Y1 - 2012

N2 - An asymmetric synthesis of 1-alkyl-2-deoxyiminofuranoses was achieved in which the Ir-catalyzed intramolecular cyclization was the key step. The diastereoselective cyclization converted an allylic carbonate into pyrrolidine derivatives. The a-glucosidase inhibitory activities of the prepared 2-deoxyiminofuranoses were also investigated.

AB - An asymmetric synthesis of 1-alkyl-2-deoxyiminofuranoses was achieved in which the Ir-catalyzed intramolecular cyclization was the key step. The diastereoselective cyclization converted an allylic carbonate into pyrrolidine derivatives. The a-glucosidase inhibitory activities of the prepared 2-deoxyiminofuranoses were also investigated.

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U2 - 10.3987/COM-12-S(N)99

DO - 10.3987/COM-12-S(N)99

M3 - 学術論文

AN - SCOPUS:84880605009

SN - 0385-5414

VL - 86

SP - 1401

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JO - Heterocycles

JF - Heterocycles

IS - 2

ER -

Asymmetric synthesis of 1-alkyl-2-deoxyiminofuranoses via the iridium-catalyzed intramolecular cyclization of an allylic carbonate

Abstract

ASJC Scopus subject areas

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