Astaxanthin as a novel mitochondrial regulator: A new aspect of carotenoids, beyond antioxidants

Yasuhiro Nishida; Allah Nawaz; Karen Hecht; Kazuyuki Tobe

doi:10.3390/nu14010107

Astaxanthin as a novel mitochondrial regulator: A new aspect of carotenoids, beyond antioxidants

Yasuhiro Nishida^*, Allah Nawaz^*, Karen Hecht, Kazuyuki Tobe^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

66 Scopus citations

Abstract

Astaxanthin is a member of the carotenoid family that is found abundantly in marine organisms, and has been gaining attention in recent years due to its varied biological/physiological activities. It has been reported that astaxanthin functions both as a pigment, and as an antioxidant with superior free radical quenching capacity. We recently reported that astaxanthin modulated mitochondrial functions by a novel mechanism independent of its antioxidant function. In this paper, we review astaxanthin’s well-known antioxidant activity, and expand on astaxanthin’s lesser-known molecular targets, and its role in mitochondrial energy metabolism.

Original language	English
Article number	107
Journal	Nutrients
Volume	14
Issue number	1
DOIs	https://doi.org/10.3390/nu14010107
State	Published - 2022/01/01

Keywords

AMPK
Astaxanthin
Energy metabolisms
Insulin resistance
Mitochondria
Natural antioxidant
Obesity

ASJC Scopus subject areas

Food Science
Nutrition and Dietetics

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abstract = "Astaxanthin is a member of the carotenoid family that is found abundantly in marine organisms, and has been gaining attention in recent years due to its varied biological/physiological activities. It has been reported that astaxanthin functions both as a pigment, and as an antioxidant with superior free radical quenching capacity. We recently reported that astaxanthin modulated mitochondrial functions by a novel mechanism independent of its antioxidant function. In this paper, we review astaxanthin{\textquoteright}s well-known antioxidant activity, and expand on astaxanthin{\textquoteright}s lesser-known molecular targets, and its role in mitochondrial energy metabolism.",

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AU - Hecht, Karen

AU - Tobe, Kazuyuki

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KW - Energy metabolisms

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Astaxanthin as a novel mitochondrial regulator: A new aspect of carotenoids, beyond antioxidants

Abstract

Keywords

ASJC Scopus subject areas

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