Anti-Vpr activities of homodrimane sesquiterpenoids and labdane diterpenoids from Globba sherwoodiana rhizomes

Prema; Takeshi Kodama; Chin Piow Wong; Ahmed H. El-Desoky; Hnin Htet Wai Nyunt; Hla Ngwe; Ikuro Abe; Hiroyuki Morita

doi:10.1016/j.fitote.2020.104705

Anti-Vpr activities of homodrimane sesquiterpenoids and labdane diterpenoids from Globba sherwoodiana rhizomes

Prema, Takeshi Kodama, Chin Piow Wong, Ahmed H. El-Desoky, Hnin Htet Wai Nyunt, Hla Ngwe, Ikuro Abe, Hiroyuki Morita^*

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Two new homodrimane sesquiterpenoids, globbatones A and B (1 and 2), and one 16-norlabdane diterpenoid, globbatone C (3), together with two new naturally occurring, (E)-labda-8(17),12-diene-15,16-olide (4) and γ-bicyclohomofarnesen-12-ol (5), and one known homodrimane sesquiterpenoid (6), nine known labdane diterpenoids (7–15), and one isospongian diterpenoid (16), were isolated from the chloroform extract of Globba sherwoodiana rhizomes. The structures of the new compounds 1–3 were elucidated based on 1D and 2D NMR and HRESIMS spectroscopic analyses. The chloroform extract of G. sherwoodiana rhizomes and 10 μM concentrations of some of its constituents 1, 3, 4, 8, 9, 12, and 14 showed the moderate anti-Vpr activities, without cytotoxic effects on the TREx-HeLa-Vpr cell line.

Original language	English
Article number	104705
Journal	Fitoterapia
Volume	146
DOIs	https://doi.org/10.1016/j.fitote.2020.104705
State	Published - 2020/10

Keywords

Globba sherwoodiana
Homodrimane sesquiterpenoids
Labdane diterpenoids
Vpr

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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@article{710a6bd9fddd44548ba5ed23bcf34557,

title = "Anti-Vpr activities of homodrimane sesquiterpenoids and labdane diterpenoids from Globba sherwoodiana rhizomes",

abstract = "Two new homodrimane sesquiterpenoids, globbatones A and B (1 and 2), and one 16-norlabdane diterpenoid, globbatone C (3), together with two new naturally occurring, (E)-labda-8(17),12-diene-15,16-olide (4) and γ-bicyclohomofarnesen-12-ol (5), and one known homodrimane sesquiterpenoid (6), nine known labdane diterpenoids (7–15), and one isospongian diterpenoid (16), were isolated from the chloroform extract of Globba sherwoodiana rhizomes. The structures of the new compounds 1–3 were elucidated based on 1D and 2D NMR and HRESIMS spectroscopic analyses. The chloroform extract of G. sherwoodiana rhizomes and 10 μM concentrations of some of its constituents 1, 3, 4, 8, 9, 12, and 14 showed the moderate anti-Vpr activities, without cytotoxic effects on the TREx-HeLa-Vpr cell line.",

keywords = "Globba sherwoodiana, Homodrimane sesquiterpenoids, Labdane diterpenoids, Vpr",

author = "Prema and Takeshi Kodama and Wong, {Chin Piow} and El-Desoky, {Ahmed H.} and Nyunt, {Hnin Htet Wai} and Hla Ngwe and Ikuro Abe and Hiroyuki Morita",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",

year = "2020",

month = oct,

doi = "10.1016/j.fitote.2020.104705",

language = "英語",

volume = "146",

journal = "Fitoterapia",

issn = "0367-326X",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Anti-Vpr activities of homodrimane sesquiterpenoids and labdane diterpenoids from Globba sherwoodiana rhizomes

AU - Prema,

AU - Kodama, Takeshi

AU - Wong, Chin Piow

AU - El-Desoky, Ahmed H.

AU - Nyunt, Hnin Htet Wai

AU - Ngwe, Hla

AU - Abe, Ikuro

AU - Morita, Hiroyuki

PY - 2020/10

Y1 - 2020/10

N2 - Two new homodrimane sesquiterpenoids, globbatones A and B (1 and 2), and one 16-norlabdane diterpenoid, globbatone C (3), together with two new naturally occurring, (E)-labda-8(17),12-diene-15,16-olide (4) and γ-bicyclohomofarnesen-12-ol (5), and one known homodrimane sesquiterpenoid (6), nine known labdane diterpenoids (7–15), and one isospongian diterpenoid (16), were isolated from the chloroform extract of Globba sherwoodiana rhizomes. The structures of the new compounds 1–3 were elucidated based on 1D and 2D NMR and HRESIMS spectroscopic analyses. The chloroform extract of G. sherwoodiana rhizomes and 10 μM concentrations of some of its constituents 1, 3, 4, 8, 9, 12, and 14 showed the moderate anti-Vpr activities, without cytotoxic effects on the TREx-HeLa-Vpr cell line.

AB - Two new homodrimane sesquiterpenoids, globbatones A and B (1 and 2), and one 16-norlabdane diterpenoid, globbatone C (3), together with two new naturally occurring, (E)-labda-8(17),12-diene-15,16-olide (4) and γ-bicyclohomofarnesen-12-ol (5), and one known homodrimane sesquiterpenoid (6), nine known labdane diterpenoids (7–15), and one isospongian diterpenoid (16), were isolated from the chloroform extract of Globba sherwoodiana rhizomes. The structures of the new compounds 1–3 were elucidated based on 1D and 2D NMR and HRESIMS spectroscopic analyses. The chloroform extract of G. sherwoodiana rhizomes and 10 μM concentrations of some of its constituents 1, 3, 4, 8, 9, 12, and 14 showed the moderate anti-Vpr activities, without cytotoxic effects on the TREx-HeLa-Vpr cell line.

KW - Globba sherwoodiana

KW - Homodrimane sesquiterpenoids

KW - Labdane diterpenoids

KW - Vpr

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U2 - 10.1016/j.fitote.2020.104705

DO - 10.1016/j.fitote.2020.104705

M3 - 学術論文

C2 - 32822767

AN - SCOPUS:85089749528

SN - 0367-326X

VL - 146

JO - Fitoterapia

JF - Fitoterapia

M1 - 104705

ER -

Anti-Vpr activities of homodrimane sesquiterpenoids and labdane diterpenoids from Globba sherwoodiana rhizomes

Abstract

Keywords

ASJC Scopus subject areas

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