TY - JOUR
T1 - Anti-Vpr activities of homodrimane sesquiterpenoids and labdane diterpenoids from Globba sherwoodiana rhizomes
AU - Prema,
AU - Kodama, Takeshi
AU - Wong, Chin Piow
AU - El-Desoky, Ahmed H.
AU - Nyunt, Hnin Htet Wai
AU - Ngwe, Hla
AU - Abe, Ikuro
AU - Morita, Hiroyuki
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/10
Y1 - 2020/10
N2 - Two new homodrimane sesquiterpenoids, globbatones A and B (1 and 2), and one 16-norlabdane diterpenoid, globbatone C (3), together with two new naturally occurring, (E)-labda-8(17),12-diene-15,16-olide (4) and γ-bicyclohomofarnesen-12-ol (5), and one known homodrimane sesquiterpenoid (6), nine known labdane diterpenoids (7–15), and one isospongian diterpenoid (16), were isolated from the chloroform extract of Globba sherwoodiana rhizomes. The structures of the new compounds 1–3 were elucidated based on 1D and 2D NMR and HRESIMS spectroscopic analyses. The chloroform extract of G. sherwoodiana rhizomes and 10 μM concentrations of some of its constituents 1, 3, 4, 8, 9, 12, and 14 showed the moderate anti-Vpr activities, without cytotoxic effects on the TREx-HeLa-Vpr cell line.
AB - Two new homodrimane sesquiterpenoids, globbatones A and B (1 and 2), and one 16-norlabdane diterpenoid, globbatone C (3), together with two new naturally occurring, (E)-labda-8(17),12-diene-15,16-olide (4) and γ-bicyclohomofarnesen-12-ol (5), and one known homodrimane sesquiterpenoid (6), nine known labdane diterpenoids (7–15), and one isospongian diterpenoid (16), were isolated from the chloroform extract of Globba sherwoodiana rhizomes. The structures of the new compounds 1–3 were elucidated based on 1D and 2D NMR and HRESIMS spectroscopic analyses. The chloroform extract of G. sherwoodiana rhizomes and 10 μM concentrations of some of its constituents 1, 3, 4, 8, 9, 12, and 14 showed the moderate anti-Vpr activities, without cytotoxic effects on the TREx-HeLa-Vpr cell line.
KW - Globba sherwoodiana
KW - Homodrimane sesquiterpenoids
KW - Labdane diterpenoids
KW - Vpr
UR - http://www.scopus.com/inward/record.url?scp=85089749528&partnerID=8YFLogxK
U2 - 10.1016/j.fitote.2020.104705
DO - 10.1016/j.fitote.2020.104705
M3 - 学術論文
C2 - 32822767
AN - SCOPUS:85089749528
SN - 0367-326X
VL - 146
JO - Fitoterapia
JF - Fitoterapia
M1 - 104705
ER -