Anti-austeritic Constituents of the Congolese Medicinal Plant Aframomum melegueta

Dya Fita Dibwe; Suresh Awale; Hiroyuki Morita; Yasuhiro Tezuka

doi:10.1177/1934578X1501000650

Anti-austeritic Constituents of the Congolese Medicinal Plant Aframomum melegueta

Dya Fita Dibwe, Suresh Awale, Hiroyuki Morita, Yasuhiro Tezuka^*

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

In the course of our search for anticancer agents based on a novel anti-austerity strategy, we found that the CHCl₃ extract of the roots of Aflamomum melegueta (Zingiberaceae), collected in the Democratic Republic of Congo, killed PANC-1 human pancreatic cancer cells preferentially in nutrient-deprived medium (NDM). Phytochemical investigation of the CHCl₃ extract led to the isolation of seven known compounds [(-)-buplerol (1), (-)-arctigenin (2), (E)-14-hydroxy-15-norlabda-8(17),12-dien-16-al (3), labda-8(17),12-dien-15,16-dial (4), 16-oxo-8(17),12(E)-labdadien-15-oic acid (5), 5-hydroxy-7-methoxyflavone (6), and apigenin (7)]. In addition to the previously reported preferentially cytotoxic compound, (-)-arctigenin (2, PC₅₀ 0.5 μM), (-)-buplerol (1) also displayed potent preferential cytotoxicity with a PC₅₀ value of 8.42 pM and triggered apoptosis-like PANC-1 cell death in NDM.

Original language	English
Journal	Natural Product Communications
Volume	10
Issue number	6
DOIs	https://doi.org/10.1177/1934578X1501000650
State	Published - 2015

Keywords

(-)-Buplerol
Aflamomum melegueta
Congolese medicinal plant
Dibenzyl-γ-butyrolactone-type lignan
Preferential cytotoxicity

ASJC Scopus subject areas

Pharmacology
Plant Science
Drug Discovery
Complementary and alternative medicine

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@article{b7124875150f4640939c7a3670f38b25,

title = "Anti-austeritic Constituents of the Congolese Medicinal Plant Aframomum melegueta",

abstract = "In the course of our search for anticancer agents based on a novel anti-austerity strategy, we found that the CHCl3 extract of the roots of Aflamomum melegueta (Zingiberaceae), collected in the Democratic Republic of Congo, killed PANC-1 human pancreatic cancer cells preferentially in nutrient-deprived medium (NDM). Phytochemical investigation of the CHCl3 extract led to the isolation of seven known compounds [(-)-buplerol (1), (-)-arctigenin (2), (E)-14-hydroxy-15-norlabda-8(17),12-dien-16-al (3), labda-8(17),12-dien-15,16-dial (4), 16-oxo-8(17),12(E)-labdadien-15-oic acid (5), 5-hydroxy-7-methoxyflavone (6), and apigenin (7)]. In addition to the previously reported preferentially cytotoxic compound, (-)-arctigenin (2, PC50 0.5 μM), (-)-buplerol (1) also displayed potent preferential cytotoxicity with a PC50 value of 8.42 pM and triggered apoptosis-like PANC-1 cell death in NDM.",

keywords = "(-)-Buplerol, Aflamomum melegueta, Congolese medicinal plant, Dibenzyl-γ-butyrolactone-type lignan, Preferential cytotoxicity",

author = "Dibwe, {Dya Fita} and Suresh Awale and Hiroyuki Morita and Yasuhiro Tezuka",

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year = "2015",

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AU - Dibwe, Dya Fita

AU - Awale, Suresh

AU - Morita, Hiroyuki

AU - Tezuka, Yasuhiro

PY - 2015

Y1 - 2015

N2 - In the course of our search for anticancer agents based on a novel anti-austerity strategy, we found that the CHCl3 extract of the roots of Aflamomum melegueta (Zingiberaceae), collected in the Democratic Republic of Congo, killed PANC-1 human pancreatic cancer cells preferentially in nutrient-deprived medium (NDM). Phytochemical investigation of the CHCl3 extract led to the isolation of seven known compounds [(-)-buplerol (1), (-)-arctigenin (2), (E)-14-hydroxy-15-norlabda-8(17),12-dien-16-al (3), labda-8(17),12-dien-15,16-dial (4), 16-oxo-8(17),12(E)-labdadien-15-oic acid (5), 5-hydroxy-7-methoxyflavone (6), and apigenin (7)]. In addition to the previously reported preferentially cytotoxic compound, (-)-arctigenin (2, PC50 0.5 μM), (-)-buplerol (1) also displayed potent preferential cytotoxicity with a PC50 value of 8.42 pM and triggered apoptosis-like PANC-1 cell death in NDM.

AB - In the course of our search for anticancer agents based on a novel anti-austerity strategy, we found that the CHCl3 extract of the roots of Aflamomum melegueta (Zingiberaceae), collected in the Democratic Republic of Congo, killed PANC-1 human pancreatic cancer cells preferentially in nutrient-deprived medium (NDM). Phytochemical investigation of the CHCl3 extract led to the isolation of seven known compounds [(-)-buplerol (1), (-)-arctigenin (2), (E)-14-hydroxy-15-norlabda-8(17),12-dien-16-al (3), labda-8(17),12-dien-15,16-dial (4), 16-oxo-8(17),12(E)-labdadien-15-oic acid (5), 5-hydroxy-7-methoxyflavone (6), and apigenin (7)]. In addition to the previously reported preferentially cytotoxic compound, (-)-arctigenin (2, PC50 0.5 μM), (-)-buplerol (1) also displayed potent preferential cytotoxicity with a PC50 value of 8.42 pM and triggered apoptosis-like PANC-1 cell death in NDM.

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KW - Congolese medicinal plant

KW - Dibenzyl-γ-butyrolactone-type lignan

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DO - 10.1177/1934578X1501000650

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Anti-austeritic Constituents of the Congolese Medicinal Plant Aframomum melegueta

Abstract

Keywords

ASJC Scopus subject areas

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