TY - JOUR
T1 - Anti-austeritic Constituents of the Congolese Medicinal Plant Aframomum melegueta
AU - Dibwe, Dya Fita
AU - Awale, Suresh
AU - Morita, Hiroyuki
AU - Tezuka, Yasuhiro
N1 - Publisher Copyright:
© 2015 SAGE Publications Inc.
PY - 2015
Y1 - 2015
N2 - In the course of our search for anticancer agents based on a novel anti-austerity strategy, we found that the CHCl3 extract of the roots of Aflamomum melegueta (Zingiberaceae), collected in the Democratic Republic of Congo, killed PANC-1 human pancreatic cancer cells preferentially in nutrient-deprived medium (NDM). Phytochemical investigation of the CHCl3 extract led to the isolation of seven known compounds [(-)-buplerol (1), (-)-arctigenin (2), (E)-14-hydroxy-15-norlabda-8(17),12-dien-16-al (3), labda-8(17),12-dien-15,16-dial (4), 16-oxo-8(17),12(E)-labdadien-15-oic acid (5), 5-hydroxy-7-methoxyflavone (6), and apigenin (7)]. In addition to the previously reported preferentially cytotoxic compound, (-)-arctigenin (2, PC50 0.5 μM), (-)-buplerol (1) also displayed potent preferential cytotoxicity with a PC50 value of 8.42 pM and triggered apoptosis-like PANC-1 cell death in NDM.
AB - In the course of our search for anticancer agents based on a novel anti-austerity strategy, we found that the CHCl3 extract of the roots of Aflamomum melegueta (Zingiberaceae), collected in the Democratic Republic of Congo, killed PANC-1 human pancreatic cancer cells preferentially in nutrient-deprived medium (NDM). Phytochemical investigation of the CHCl3 extract led to the isolation of seven known compounds [(-)-buplerol (1), (-)-arctigenin (2), (E)-14-hydroxy-15-norlabda-8(17),12-dien-16-al (3), labda-8(17),12-dien-15,16-dial (4), 16-oxo-8(17),12(E)-labdadien-15-oic acid (5), 5-hydroxy-7-methoxyflavone (6), and apigenin (7)]. In addition to the previously reported preferentially cytotoxic compound, (-)-arctigenin (2, PC50 0.5 μM), (-)-buplerol (1) also displayed potent preferential cytotoxicity with a PC50 value of 8.42 pM and triggered apoptosis-like PANC-1 cell death in NDM.
KW - (-)-Buplerol
KW - Aflamomum melegueta
KW - Congolese medicinal plant
KW - Dibenzyl-γ-butyrolactone-type lignan
KW - Preferential cytotoxicity
UR - http://www.scopus.com/inward/record.url?scp=85027892070&partnerID=8YFLogxK
U2 - 10.1177/1934578X1501000650
DO - 10.1177/1934578X1501000650
M3 - 学術論文
C2 - 26197535
AN - SCOPUS:85027892070
SN - 1934-578X
VL - 10
JO - Natural Product Communications
JF - Natural Product Communications
IS - 6
ER -