Abstract
A new limonoid, 6α,7α-diacetoxy-3-oxo-24,25,26,27-tetranorapotirucalla-1,14,20(22)-trien-21,23-lactam (1), was isolated from the fruits of Chisocheton paniculatus Hiern collected in Vietnam, together with two known 5α,8α-epidioxysterols, (22E,24R)-5α,8α-epidioxy-24-methyl-cholesta-6,22-dien-3β-ol (2) and (22E,24R)-5α,8α-epidioxy-24-methyl-cholesta-6,9(11),22-trien-3β-ol (3). Their structures were elucidated by spectroscopic analyses, including 1D- and 2D-NMR and HRESIMS, and comparisons with the reported data in the literature. Compounds 1-3 exhibited the NO production inhibitory activities against the LPS stimulated BV2 cells with 69.0 ± 2.7 %, 69.5 ± 2.2 %, and 70.6 ± 1.6 %, at concentration of 20.0 μM, respectively.
| Original language | English |
|---|---|
| Pages (from-to) | 1255-1257 |
| Number of pages | 3 |
| Journal | Natural Product Communications |
| Volume | 13 |
| Issue number | 10 |
| DOIs | |
| State | Published - 2018/10 |
Keywords
- Chisocheton paniculatus
- Limonoid
- NO inhibitor
- Tetranortriterpenoid
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery
- Plant Science
- Complementary and alternative medicine