TY - JOUR
T1 - A new limonoid from Chisocheton paniculatus fruit collected in Vietnam and its NO production inhibitory activity
AU - Hoai, Nguyen Thi
AU - Duc, Ho Viet
AU - Raal, Ain
AU - Morita, Hiroyuki
N1 - Publisher Copyright:
© Copyright 2018 Natural Product Communciations Inc. All Rights Reserved.
PY - 2018/10
Y1 - 2018/10
N2 - A new limonoid, 6α,7α-diacetoxy-3-oxo-24,25,26,27-tetranorapotirucalla-1,14,20(22)-trien-21,23-lactam (1), was isolated from the fruits of Chisocheton paniculatus Hiern collected in Vietnam, together with two known 5α,8α-epidioxysterols, (22E,24R)-5α,8α-epidioxy-24-methyl-cholesta-6,22-dien-3β-ol (2) and (22E,24R)-5α,8α-epidioxy-24-methyl-cholesta-6,9(11),22-trien-3β-ol (3). Their structures were elucidated by spectroscopic analyses, including 1D- and 2D-NMR and HRESIMS, and comparisons with the reported data in the literature. Compounds 1-3 exhibited the NO production inhibitory activities against the LPS stimulated BV2 cells with 69.0 ± 2.7 %, 69.5 ± 2.2 %, and 70.6 ± 1.6 %, at concentration of 20.0 μM, respectively.
AB - A new limonoid, 6α,7α-diacetoxy-3-oxo-24,25,26,27-tetranorapotirucalla-1,14,20(22)-trien-21,23-lactam (1), was isolated from the fruits of Chisocheton paniculatus Hiern collected in Vietnam, together with two known 5α,8α-epidioxysterols, (22E,24R)-5α,8α-epidioxy-24-methyl-cholesta-6,22-dien-3β-ol (2) and (22E,24R)-5α,8α-epidioxy-24-methyl-cholesta-6,9(11),22-trien-3β-ol (3). Their structures were elucidated by spectroscopic analyses, including 1D- and 2D-NMR and HRESIMS, and comparisons with the reported data in the literature. Compounds 1-3 exhibited the NO production inhibitory activities against the LPS stimulated BV2 cells with 69.0 ± 2.7 %, 69.5 ± 2.2 %, and 70.6 ± 1.6 %, at concentration of 20.0 μM, respectively.
KW - Chisocheton paniculatus
KW - Limonoid
KW - NO inhibitor
KW - Tetranortriterpenoid
UR - http://www.scopus.com/inward/record.url?scp=85055797701&partnerID=8YFLogxK
U2 - 10.1177/1934578x1801301005
DO - 10.1177/1934578x1801301005
M3 - 学術論文
AN - SCOPUS:85055797701
SN - 1934-578X
VL - 13
SP - 1255
EP - 1257
JO - Natural Product Communications
JF - Natural Product Communications
IS - 10
ER -