Sharing pathogenic mechanism between non-alcoholic steatohepatitis and primary biliary cirrhosis

Research output

Research output per year 2009 2009 2010 2011 2012

• 46 Article
• 21 Presentation
• 1 Conference contribution

Research output per year

Research output per year

Search results

• 2012

  Cattle bile but not bear bile or pig bile induces lipid profile changes and fatty liver injury in mice: Mediation by cholic acid

  Watanabe, S. & Tsuneyama, K., 2012/02, In: Journal of Toxicological Sciences. 37, 1, p. 105-121 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cholic Acid 100%
  • Cattle Bile 100%
  • Pig Bile 100%
  • Bear Bile 100%
  • Fatty Liver Injury 100%
  19 Scopus citations

• Comparative analysis of portal cell infiltrates in AMAy-positive versus AMA-negative PBC

  Q, J., Y, M., A, L., K, T. & al., E., 2012, In: Hepatology. 55(5), p. 1495-506

  Research output: Contribution to journal › Article › peer-review

• Identification of Innate IL-5-Producing Cells and Their Role in Lung Eosinophil Regulation and Antitumor Immunity

  Ikutani, M., Yanagibashi, T., Ogasawara, M., Tsuneyama, K., Yamamoto, S., Hattori, Y., Kouro, T., Itakura, A., Nagai, Y., Takaki, S. & Takatsu, K., 2012/01/15, In: Journal of Immunology. 188, 2, p. 703-713 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tumor Immunity 100%
  • Lung 100%
  • Eosinophils 100%
  • Interleukin-5 (IL-5) 100%
  • Eosinophil 100%
  267 Scopus citations

• Involvement of immune-related factors in diclofenac-induced acute liver injury in mice

  A., Y., 2012, In: Toxicology. 293(1-3), 1-3, p. 107-114

  Research output: Contribution to journal › Article › peer-review

• Mechanism of exacerbative effect of progesterone on drug-induced liver injury

  Y, T., S, E., K, T. & al., E., 2012, In: Journal of Toxicological Sciences. 126(1), p. 16-27

  Research output: Contribution to journal › Article › peer-review

• Pathological characteristics of the Iidney and bone of patients with itai-itai disease (chronic cadmium toxicity)

  K., T., 2012.

  Research output: Contribution to conference › Presentation

• Pathological features of new animal models for primary biliary cirrhosis.

  K, T. & al., E., 2012, In: Int J Hepatol.. 2012, p. 1-7

  Research output: Contribution to journal › Article › peer-review

• Plasma cells and the chronic nonsuppurative destructive cholangitis of primary biliary cirrhosis.

  T, T., T, M., J, N., S, Y., T, M., M, Y., Y, M., H, U., I, E., K, T. & al., E., 2012, In: Hepatology. 55(3), 3, p. 846-855

  Research output: Contribution to journal › Article › peer-review

• Serum soluble MD-1 levels increase with disease progression in autoimmune prone MRL(lprApr) mice.

  S, S., Y, N., T, Y., Y, W., M, I., A, K., K, T. & al., E., 2012, In: Molecular Immunology. 49(4), 4, p. 611-620

  Research output: Contribution to journal › Article › peer-review

• Spirulina improves non-alcoholic steatohepatitis, visceral fat macrophage aggregation, and serum leptin in a mouse model of metabolic syndrome

  Fujimoto, M., Tsuneyama, K., Fujimoto, T., Selmi, C., Gershwin, M. E. & Shimada, Y., 2012/09, In: Digestive and Liver Disease. 44, 9, p. 767-774 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Nonalcoholic Steatohepatitis 100%
  • Mouse Model 100%
  • Metabolic Syndrome 100%
  • Macrophages 100%
  • Serum Leptin 100%
  59 Scopus citations

• The role of natural killer(NK) and NK T cells in the loss of tolerance in murine PBC

  S, S., K, T. & al., E., 2012, In: Clinical and Experimental Immunology. 168(3), p. 279-284

  Research output: Contribution to journal › Article › peer-review
• 2011

  Advantages and disadvantages of hyperbaric oxygen treatment in mice with obesity hyperlipidemia and steatohepatitis

  Tsuneyama, K., Chen, Y. C., Fujimoto, M., Sasaki, Y., Suzuki, W., Shimada, T., Iizuka, S., Nagata, M., Aburada, M. & Chen, S. Y., 2011, In: Scientific World Journal. 11, p. 2124-2135 12 p., 380236.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Obesity 100%
  • Steatohepatitis 100%
  • Hyperbaric Oxygen Therapy 100%
  • Hyperlipidemia 100%
  • Oxygen Therapy 100%
  21 Scopus citations

• B cell depletion therapy exacerbates murine PBC

  A, D., A, L., GX, Y., K, T. & al., E., 2011, In: Hepatology. 53(2), p. 527-35

  Research output: Contribution to journal › Article › peer-review

• B cells promote hepatic inflammation, biliary cyst formation, and salivary gland inflammation in the NOD. c3c4 model of autoimmune cholangitis

  Y, M., M, T., K, T. & al., E., 2011, In: Immunology and Cell Biology. 268(1), p. 16-23

  Research output: Contribution to journal › Article › peer-review

• B cells promote hepatic inflammation, biliary cyst formation, and salivary gland inflammation in the NOD.c3c4 model of autoimmune cholangitis.

  Y, M., M, T., K, T. & al., E., 2011, In: Immunology and Cell Biology. 268(1), p. 16-23

  Research output: Contribution to journal › Article › peer-review

• Effects of bezafibrate in nonalcoholic steatohepatitis model mice with monosodium glutamate-induced metabolic syndrome

  Y., S., 2011, In: European Journal of Pharmacology: Molecular Pharmacology. 662(1-3), 1-3, p. 1-8

  Research output: Contribution to journal › Article › peer-review

• Estradiol and progesterone modulate halothane-induced liver injury in mice

  Y, T., T, M., S, E., K, T. & al., E., 2011, In: Toxicology Letters. 204(1), p. 17-24

  Research output: Contribution to journal › Article › peer-review

• Fine phenotypic and functional characterization of effector cluster of differentiation 8 positive T cells in human patients with primary biliary cirrhosis

  M., T., 2011, In: Hepatology. 54(4), 4, p. 1293-1302

  Research output: Contribution to journal › Article › peer-review

• IL-4 mediates dicloxacillin-induced liver injury in mice.

  S, H., M, K., Y, Y., K, T. & al., E., 2011, In: Toxicology Letters. 200(3), p. 139-145

  Research output: Contribution to journal › Article › peer-review

• Innate immunity and primary biliary cirrhosis : activated invariantnatural killer T cells exacerbate murine autoimmune cholangitis and fibrosis

  SJ, W., YH, Y., K, T. & al., E., 2011, In: Hepatology. 53(3), p. 915-25

  Research output: Contribution to journal › Article › peer-review

• Innate immunity and primary biliary cirrhosis : Activated invariant natural killer T cells exacerbate murine autoimmune cholangitiS and fibrosis

  SJ, W., YH, Y., K, T. & al., E., 2011, In: Hepatology. 53(3), p. 915-925

  Research output: Contribution to journal › Article › peer-review

• Interaction between Toll-like receptors and natural killer cells in the destruction of bile ducts in primary biliary cirrhosis

  S., S., 2011, In: Hepatology. 53(4), 4, p. 1270-1281

  Research output: Contribution to journal › Article › peer-review

• Septic shock is associated with receptor for advanced glycation end products ligation of LPS.

  Y, Y., A, H., H, S., K, T. & al., E., 2011, In: J Immunol.. 186(5), p. 3248-3257

  Research output: Contribution to journal › Article › peer-review

• Telmisartan improves insulin resistance and modulates adipose tissue macrophage polarization in high-fat-fed mice

  Fujisaka, S., Usui, I., Kanatani, Y., Ikutani, M., Takasaki, I., Tsuneyama, K., Tabuchi, Y., Bukhari, A., Yamazaki, Y., Suzuki, H., Senda, S., Aminuddin, A., Nagai, Y., Takatsu, K., Kobayashi, M. & Tobe, K., 2011/05, In: Endocrinology. 152, 5, p. 1789-1799 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Insulin Resistance 100%
  • Telmisartan 100%
  • Adipose Tissue Macrophages 100%
  • High-fat Diet Mice 100%
  • Macrophage Polarization 100%
  91 Scopus citations

• The multi-hit hypothesis of primary biliary cirrhosis : polyinosinic-polycytidylic acid (poly I:C) and murine autoimmune cholangitis

  YM., A., 2011, In: Clinical and Experimental Immunology. 166(1), 1, p. 110-120

  Research output: Contribution to journal › Article › peer-review

• 深層水の医療分野への応用について

  常山幸一, 2011.

  Research output: Contribution to conference › Presentation

• 肝疾患モデル動物

  常山幸一, 2011.

  Research output: Contribution to conference › Presentation

• 自然発症肥満・糖尿病・NASHモデル(TSOD)マウス脾臓における異常鉄沈着の病理組織学的検討

  常山幸一 & 他, 2011.

  Research output: Contribution to conference › Presentation
• 2010

  Application of a new histological staging and grading system for primary biliary cirrhosis to liver biopsy specimens : Interobserver agreement.

  Y, N., Y, Z., K, H., M, S., A, N., T, U., K, S., F, K., T, F., K, T. & al, E., 2010, In: Pathol Int. 60(3). p. 167-174

  Research output: Contribution to journal › Article › peer-review

• Autoimmune biliary damages and NASH

  K, T., 2010.

  Research output: Contribution to conference › Presentation

• Autoimmune biliary damages and NASH.

  Tsuneyama, K., 2010.

  Research output: Contribution to conference › Presentation

• Autoimmune Liver injury and Non-alcoholic fatty liver disease.

  J, L., J, W., K, T. & Y., L., 2010, In: Chinese J.Gastroenterol.. 15(9), p. 525-527

  Research output: Contribution to journal › Article › peer-review

• B cell depletion therapy exacerbates murine primary biliary cirrhosis.

  A, D., A, L., GX, Y., K, T. & al., E., 2010, In: Hepatology. 53(2), p. 527-535

  Research output: Contribution to journal › Article › peer-review

• Deletion of interleukin-6 in mice with the dominant negative form of transforming growth factor beta receptor II improves colitis but exacerbates autoimmune cholangitis

  W, Z., M, T., GX, Y., K, T. & al., E., 2010, In: Hepatology. 52(1), p. 215-22

  Research output: Contribution to journal › Article › peer-review

• Deletion of interleukin-6 in mice with the dominant negative form of transforming growth factor beta receptor II improves colitis but exacerbates autoimmune cholangitis.

  W, Z., M, T., GX, Y., suneyama K, T. & al., E., 2010, In: Hepatology. 52(1), p. 215-222

  Research output: Contribution to journal › Article › peer-review

• Development of an ultrasound-emitting device for performing rapid immunostaining procedures

  Hatta, H., Tsuneyama, K., Kondo, T. & Takano, Y., 2010/05, In: Journal of Histochemistry and Cytochemistry. 58, 5, p. 421-428 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ultrasound 100%
  • Immunostaining 100%
  • Ultrasonics 100%
  • Emitting Device 100%
  • Immunohistochemistry 100%
  13 Scopus citations

• Endometrioid adenocarcinoma of the vagina with a microglandular pattern arising from endometriosis after hysterectomy

  Nomoto, K., Hori, T., Kiya, C., Fukuoka, J., Nakashima, A., Hidaka, T., Saito, S., Mikami, Y., Tsuneyama, K. & Takano, Y., 2010/09, In: Pathology International. 60, 9, p. 636-641 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Endometriosis 100%
  • Hysterectomy 100%
  • Endometrioid Adenocarcinoma 100%
  • Microglandular 100%
  • Adenocarcinoma 100%
  9 Scopus citations

• Evidence-based efficacy of Chinese herbal medicine and functional foods in animal models of metabolic syndrome associated liver diseases

  K, T., 2010.

  Research output: Contribution to conference › Presentation

• Evidence-based efficacy of Chinese herbal medicine and functional foods in animal models of metabolic syndrome associated liver diseases.

  Tsuneyama, K., 2010.

  Research output: Contribution to conference › Presentation

• Interleukin-17 is involved in alpha-naphthylisothiocyanate-induced liver injury in mice.

  M, K., S, H., K, M., K, T. & al., E., 2010, In: Toxicology. 10,275(1-3):, p. 50-57

  Research output: Contribution to journal › Article › peer-review

• Kangen-karyu improves memory deficit caused by aging through normalization of neuro-plasticity-related signaling system and VEGF system in the brain

  Zhao, Q., Yokozawa, T., Yamabe, N., Tsuneyama, K., Li, X. & Matsumoto, K., 2010/09, In: Journal of Ethnopharmacology. 131, 2, p. 377-385 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Aging 100%
  • Vascular Endothelial Growth Factor 100%
  • Signaling System 100%
  • Memory Deficits 100%
  • SAMP8 100%
  23 Scopus citations

• Nutrition, geoepidemiology, and autoimmunity

  C, S. & K., T., 2010, In: Autoimmunity Reviews. 9(5)

  Research output: Contribution to journal › Article › peer-review

• Olive leaf extract prevents spontaneous occurrence of non-alcoholic steat ohepatitis in SHR/NDmcr-cp rats.

  K, O., S, K., K, T. & al., E., 2010, In: Human Pathology. p. 66-72

  Research output: Contribution to journal › Article › peer-review

• Pathological characterization of new animal models of Primary Biliary Cirrhosis

  K., T., 2010.

  Research output: Contribution to conference › Presentation

• Spirulina and its constituent phycocyanin improve visceral fat macrophage aggregation, serum adiponectin level, and stea tohepatitis in a mouse model of NAFLD associated with metabolic syndrome

  Tsuneyama, K., 2010.

  Research output: Contribution to conference › Presentation

• The traditional Japanese formula keishibukuryogan reduces liver injury and inflammation in patients with nonalcoholic fatty liver disease

  Fujimoto, M., Tsuneyama, K., Kinoshita, H., Goto, H., Takano, Y., Selmi, C., Keen, C. L., Gershwin, M. E. & Shimada, Y., 2010/03, Foods for Health in the 21st Century: A Roadmap for the Future. Blackwell Publishing Inc., p. 151-158 8 p. (Annals of the New York Academy of Sciences; vol. 1190).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Non-alcoholic Fatty Liver Disease (NAFLD) 100%
  • Liver Inflammation 100%
  • Keishibukuryogan 100%
  • Liver Injury 100%
  • Nonalcoholic Fatty Liver 100%
  30 Scopus citations

• Treatment of hepatocellular carcinoma with adeno-associated virus encoding interleukin-15 superagonist.

  CM, C., CH, L., YM, S., Y, C., PY, W., K, T. & al, E., 2010, In: Hum Gene Ther. 21(5). p. 611-621

  Research output: Contribution to journal › Article › peer-review

• TSOD mouse : a new spontaneous model of nonalcoholic steatohepatitis and hepatocellular carcinoma associated with obesity, type 2 diabetes, and hyperlipidemia

  K, T. & al., E., 2010.

  Research output: Contribution to conference › Presentation

• TSODマウスにおける異常鉄沈着の病理組織学的検討

  常山幸一, 西田健志 & 藤本誠, 2010.

  Research output: Contribution to conference › Presentation

• Usefulness of positron emission tomography for management of ocular sebaceous carcinoma

  Yasumura, S., Shojaku, H., Wada, R., Watanabe, Y., Shojaku, H., Seto, H., Kawano, M. & Tsuneyama, K., 2010/02, In: Clinical Nuclear Medicine. 35, 2, p. 98-100 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Positron Emission Tomography 100%
  • Sebaceous Carcinoma 100%
  • Distant Metastasis 40%
  • Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) 40%
  • Polyethylene Terephthalate 40%
  3 Scopus citations