Research output per year
Research output per year
Project Details
Abstract
Our in vivo and in vitro studies revealed that PGD_2 and PGE_2, which are major prostaglandins in the brain, were eliminated from rat cerebroventricle across the blood-cerebrospinal fluid barrier(BCSFB). To examine the involvement of brain-type prostaglandin transporter(PGT-Br) in this elimination process, PGT-Br-expressing Xenopus Laevis oocytes were established. The PGD_2 uptake activity into PGT-Br-expressing oocytes was high, but not significantly altered, compared with water-injected oocytes
| Status | Finished |
|---|---|
| Effective start/end date | 2009/01/01 → 2011/12/31 |
Funding
- Japan Society for the Promotion of Science: ¥18,330,000.00
Keywords
- クリアランス
- トランスポーター
- プロスタグランジン
- 有機アニオン輸送担体
- 脳・神経
- 脳脊髄液
- 脳関門
- 血液脳脊髄液関門
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Amyloid-β peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier
Fujiyoshi, M., Tachikawa, M., Ohtsuki, S., Ito, S., Uchida, Y., Akanuma, S. I., Kamiie, J., Hashimoto, T., Hosoya, K. I., Iwatsubo, T. & Terasaki, T., 2011/08, In: Journal of Neurochemistry. 118, 3, p. 407-415 9 p.Research output: Contribution to journal › Article › peer-review
53 Scopus citations -
Anti-ribosomal P antibodies and lupus nephritis
Hosoya, K. I. & Tachikawa, M., 2011/08, In: Clinical and Experimental Nephrology. 15, 4, p. 478-485 8 p.Research output: Contribution to journal › Review article › peer-review
74 Scopus citations -
Attenuation of prostaglandin E 2 elimination across the mouse blood-brain barrier in lipopolysaccharide-induced inflammation and additive inhibitory effect of cefmetazole
Akanuma, S. I., Uchida, Y., Ohtsuki, S., Tachikawa, M., Terasaki, T. & Hosoya, K. I., 2011/10/21, In: Fluids and Barriers of the CNS. 8, 1, 24.Research output: Contribution to journal › Article › peer-review
Open Access34 Scopus citations