Research output per year
Research output per year
Project Details
Abstract
In obese adipose tissues, the number of inflammatory M1 macrophage is dramatically increased and the ratio of antiinflammatory M2 macrophage is reduced, resulting the decrease of insulin sensitivity and development of obesity complications(Diabetes 58 : 2574-2582, 2009). I found that telmisartan, an angiotensin II type I receptor blocker, improved insulin resistance with its PPARγactivity, by modulating M1/M2 macrophage ratio(Endocrinology, 152 : 1789-1799, 2011). I also found that obesity-induced hypoxia in adipose tissue is involved in M1 polarization of macrophages.
| Status | Finished |
|---|---|
| Effective start/end date | 2009/01/01 → 2011/12/31 |
Funding
- Japan Society for the Promotion of Science: ¥4,940,000.00
Keywords
- 肥満
- 脂肪組織
- 炎症
- インスリン抵抗性
- マクロファージ
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The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation
Watanabe, Y., Nakamura, T., Ishikawa, S., Fujisaka, S., Usui, I., Tsuneyama, K., Ichihara, Y., Wada, T., Hirata, Y., Suganami, T., Izaki, H., Akira, S., Miyake, K., Kanayama, H. O., Shimabukuro, M., Sata, M., Sasaoka, T., Ogawa, Y., Tobe, K. & Takatsu, K. & 1 others, , 2012/05, In: Diabetes. 61, 5, p. 1199-1209 11 p.Research output: Contribution to journal › Article › peer-review
Open Access41 Scopus citations -
Deletion of platelet-derived growth factor receptor-βimproves diabetic nephropathy in Ca2+/calmodulin-dependent protein kinase IIα(Thr286 Asp) transgenic mice
H., S., I., U., I., K., T., O., Y., K., Y., Y., S., F., S., S., Y., I., M., U., A., M., S., T., H., O., M., K., K., T. & M., S., 2011, In: Diabetologia 2011. 54, p. 2953-2962Research output: Contribution to journal › Article › peer-review
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Deletion of platelet-derived growth factor receptor-βimproves diabetic nephropathy in Ca2+/calmodulin-dependent protein kinase II α (Thr286 Asp) transgenic mice
H., S., I., U., I., K., T., O., Y., K., Y., Y., S., F., S., S., Y., I., M., U., A., M., S., T., H., O., M., K., be K., T. & M, S., 2011, In: Diabetologia. 54, p. 2953-2962Research output: Contribution to journal › Article › peer-review