Research output per year
Research output per year
Project Details
Abstract
3. RP105/MD-1の内因性リガンドの探索と脂肪組織炎症との関連、RP105/MD-1を標的とした治療の基礎的探索RP105/MD-1の内因性リガンド探索を目的とし、脂肪組織や血清を用いたメタボローム解析を継続中である。また、ヒト内臓脂肪組織におけるRP105 mRNA発現と肥満度を示すBody mass indexとの間に有意な相関性を認めることを見出した。
| Status | Finished |
|---|---|
| Effective start/end date | 2010/01/01 → 2011/12/31 |
Funding
- Japan Society for the Promotion of Science: ¥9,100,000.00
Keywords
- 免疫学
- 脂質
- 肥満
- 自然免疫
- Toll-like receptor
Research output
- 4 Article
-
Glycyrrhizin and isoliquiritigenin suppress the LPS sensor Toll-like receptor 4/MD-2 complex signaling in a different manner
Honda, H., Nagai, Y., Matsunaga, T., Saitoh, S. I., Akashi-Takamura, S., Hayashi, H., Fujii, I., Miyake, K., Muraguchi, A. & Takatsu, K., 2012/06, In: Journal of Leukocyte Biology. 91, 6, p. 967-976 10 p.Research output: Contribution to journal › Article › peer-review
94 Scopus citations -
Identification of Innate IL-5-Producing Cells and Their Role in Lung Eosinophil Regulation and Antitumor Immunity
Ikutani, M., Yanagibashi, T., Ogasawara, M., Tsuneyama, K., Yamamoto, S., Hattori, Y., Kouro, T., Itakura, A., Nagai, Y., Takaki, S. & Takatsu, K., 2012/01/15, In: Journal of Immunology. 188, 2, p. 703-713 11 p.Research output: Contribution to journal › Article › peer-review
Open Access269 Scopus citations -
The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation
Watanabe, Y., Nakamura, T., Ishikawa, S., Fujisaka, S., Usui, I., Tsuneyama, K., Ichihara, Y., Wada, T., Hirata, Y., Suganami, T., Izaki, H., Akira, S., Miyake, K., Kanayama, H. O., Shimabukuro, M., Sata, M., Sasaoka, T., Ogawa, Y., Tobe, K. & Takatsu, K. & 1 others, , 2012/05, In: Diabetes. 61, 5, p. 1199-1209 11 p.Research output: Contribution to journal › Article › peer-review
Open Access41 Scopus citations