the metabolic changes in macrophages that promote obesity-associated liver cancer

Since HIF-1α of liver mφ in obese mice was activated in hypoxia-independent manner, intracellular metabolites of liver mφ was analyzed. However, succinate and other metabolites, which had been speculated to activate HIF-1α, did not change between obese and lean mice. Further studies are needed to identify the factors activating the HIF-1α in liver mφ during obesity in the future.

mφ内でHIF-1αを活性化する代謝物の同定には至らず、肝臓マクロファージの抽出、メタボローム解析の手法の見直し、変更が必要であると考えられた。mφHIF-1αを活性化する因子の同定は今後の課題である。