In this study, for developing novel therapeutic strategy on the neurodegenerative diseases, the inhibitory effects of anti-inflammatory drugs on neuroinflammation using the nose-to-brain drug delivery system has been investigated. First of all, the formulation development for intranasal application that can achieve efficient drug delivery from the nose to brain was conducted. As a result of preparing solid formulations in various dosage forms, it was found that the powder formulation can improve the dissolution behavior in the nasal mucus and have good nebulization properties. the powder formulation improved the brain delivery of anti-inflammatory drugs after intranasal administration. Currently, it is continuing to investigate the anti-inflammatory effect of neuroinflammation on a LPS-induced model rats using the powder formulation of anti-inflammatory drugs developed in this study.