Research output per year
Research output per year
Project Details
Abstract
In vivo and in vitro analyses were performed to study transport mechanisms for cationic drugs, such as [^3H]verapamil, at the blood-retinal barrier （BRB).The results obtained suggested the involvement of carrier-mediated transport system in the influx transport of cationic drugs across the inner BRB. Furthermore, orphan transporters were identified as candidate molecules responsible for drug transport at the inner BRB.
| Status | Finished |
|---|---|
| Effective start/end date | 2011/01/01 → 2012/12/31 |
Funding
- Japan Society for the Promotion of Science: ¥3,250,000.00
Keywords
- 血液網膜関門
- トランスポーター
- 薬物送達
- オーファン分子
- 薬物動態
- 毒性
- 薬効
- インフラックス
- 血液-網膜関門
Research output
- 3 Article
-
Involvement of a novel organic cation transporter in verapamil transport across the inner blood-retinal barrier
Kubo, Y., Kusagawa, Y., Tachikawa, M., Akanuma, S. I. & Hosoya, K. I., 2013/03, In: Pharmaceutical Research. 30, 3, p. 847-856 10 p.Research output: Contribution to journal › Article › peer-review
45 Scopus citations -
Propranolol Transport Across the Inner Blood-Retinal Barrier: Potential Involvement of a Novel Organic Cation Transporter
Kubo, Y., Shimizu, Y., Kusagawa, Y., Akanuma, S. I. & Hosoya, K. I., 2013/09, In: Journal of Pharmaceutical Sciences. 102, 9, p. 3332-3342 11 p.Research output: Contribution to journal › Article › peer-review
Open Access43 Scopus citations -
Application of membrane permeability evaluated in in vitro analyses to estimate blood-retinal barrier permeability
Kubo, Y., Fukui, E., Akanuma, S. I., Tachikawa, M. & Hosoya, K. I., 2012/07, In: Journal of Pharmaceutical Sciences. 101, 7, p. 2596-2605 10 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations