Noble method for evaluation of the drug induced QT prolongation in patients with atrial fibrillation and associated gene abnormality

  • 水牧, 功一 (Principal Investigator)
  • 市田, 蕗子 (Co-Investigator(Kenkyū-buntansha))

Project Details

Outline of Final Research Achievements

We established reliable methods for assessing QT/RR relation during atrial fibrillation (AF) using Holter ECG. Moreover, in patients with paroxysmal AF, bradycardia-dependent QT prolongation was attenuated during AF, and was corrected and gradually augmented along with continuation of SR, especially in patients receiving antiarrhythmic drugs. This could increase the risk of developing torsade de pointes (TdP). In both in vivo and in vitro studies, patients with KCNE1(G38S) had a rate-dependent repolarization abnormality similar to patients with LQT2, and therefore may have a potential risk to developTdP.
StatusFinished
Effective start/end date2012/04/01 → 2016/03/31

Funding

  • Japan Society for the Promotion of Science: ¥5,200,000.00

Keywords

  • QT延長症候群
  • 心房細動
  • ホルター心電図
  • 遺伝子解析
  • イオンチャネル
  • 薬剤性QT延長症候群
  • 遺伝子

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