Abnormal repolarization dynamics in a patient with KCNE1 (G38S) who presented with torsades de pointes

Yoshiaki Yamaguchi; Koichi Mizumaki; Yukiko Hata; Hiroshi Inoue

doi:10.1016/j.jelectrocard.2015.10.002

Abnormal repolarization dynamics in a patient with KCNE1 (G38S) who presented with torsades de pointes

Yoshiaki Yamaguchi, Koichi Mizumaki^*, Yukiko Hata, Hiroshi Inoue

^*Corresponding author for this work

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Abstract

Risk of G38S, major KCNE1 polymorphism [KCNE1(G38S)], for long QT syndrome (LQTS) remains unclear. A 72-year-old woman was admitted with recurrent torsades de pointes (TdP). She had remarkable QT prolongation (corrected QT interval 568 ms) under conditions of hypokalemia and hypomagnesemia. After correction of this electrolytic imbalance, TdP was suppressed and metoprolol was started. The QT-RR slope in 24-hour Holter electrocardiogram was steep and this enhanced bradycardia-dependent QT prolongation was similar to that in LQTS. She carried KCNE1(G38S). Patients with KCNE1(G38S) could have similar potential risk of ventricular arrhythmia as with LQTS. Analysis of QT-RR relationship could also evaluate the latent arrhythmogenicity of KCNE1(G38S).

Original language	English
Pages (from-to)	94-98
Number of pages	5
Journal	Journal of Electrocardiology
Volume	49
Issue number	1
DOIs	https://doi.org/10.1016/j.jelectrocard.2015.10.002
State	Published - 2016

Keywords

KCNE1(G38S)
QT-RR relation
hypokalemia
hypomagnesemia
long QT syndrome

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.jelectrocard.2015.10.002

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@article{940aaa2cd1274deda39a029f2dab5925,

title = "Abnormal repolarization dynamics in a patient with KCNE1 (G38S) who presented with torsades de pointes",

abstract = "Risk of G38S, major KCNE1 polymorphism [KCNE1(G38S)], for long QT syndrome (LQTS) remains unclear. A 72-year-old woman was admitted with recurrent torsades de pointes (TdP). She had remarkable QT prolongation (corrected QT interval 568 ms) under conditions of hypokalemia and hypomagnesemia. After correction of this electrolytic imbalance, TdP was suppressed and metoprolol was started. The QT-RR slope in 24-hour Holter electrocardiogram was steep and this enhanced bradycardia-dependent QT prolongation was similar to that in LQTS. She carried KCNE1(G38S). Patients with KCNE1(G38S) could have similar potential risk of ventricular arrhythmia as with LQTS. Analysis of QT-RR relationship could also evaluate the latent arrhythmogenicity of KCNE1(G38S).",

keywords = "KCNE1(G38S), QT-RR relation, hypokalemia, hypomagnesemia, long QT syndrome",

author = "Yoshiaki Yamaguchi and Koichi Mizumaki and Yukiko Hata and Hiroshi Inoue",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

year = "2016",

doi = "10.1016/j.jelectrocard.2015.10.002",

language = "英語",

volume = "49",

pages = "94--98",

journal = "Journal of Electrocardiology",

issn = "0022-0736",

publisher = "Elsevier B.V.",

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}

TY - JOUR

T1 - Abnormal repolarization dynamics in a patient with KCNE1 (G38S) who presented with torsades de pointes

AU - Yamaguchi, Yoshiaki

AU - Mizumaki, Koichi

AU - Hata, Yukiko

AU - Inoue, Hiroshi

PY - 2016

Y1 - 2016

N2 - Risk of G38S, major KCNE1 polymorphism [KCNE1(G38S)], for long QT syndrome (LQTS) remains unclear. A 72-year-old woman was admitted with recurrent torsades de pointes (TdP). She had remarkable QT prolongation (corrected QT interval 568 ms) under conditions of hypokalemia and hypomagnesemia. After correction of this electrolytic imbalance, TdP was suppressed and metoprolol was started. The QT-RR slope in 24-hour Holter electrocardiogram was steep and this enhanced bradycardia-dependent QT prolongation was similar to that in LQTS. She carried KCNE1(G38S). Patients with KCNE1(G38S) could have similar potential risk of ventricular arrhythmia as with LQTS. Analysis of QT-RR relationship could also evaluate the latent arrhythmogenicity of KCNE1(G38S).

AB - Risk of G38S, major KCNE1 polymorphism [KCNE1(G38S)], for long QT syndrome (LQTS) remains unclear. A 72-year-old woman was admitted with recurrent torsades de pointes (TdP). She had remarkable QT prolongation (corrected QT interval 568 ms) under conditions of hypokalemia and hypomagnesemia. After correction of this electrolytic imbalance, TdP was suppressed and metoprolol was started. The QT-RR slope in 24-hour Holter electrocardiogram was steep and this enhanced bradycardia-dependent QT prolongation was similar to that in LQTS. She carried KCNE1(G38S). Patients with KCNE1(G38S) could have similar potential risk of ventricular arrhythmia as with LQTS. Analysis of QT-RR relationship could also evaluate the latent arrhythmogenicity of KCNE1(G38S).

KW - KCNE1(G38S)

KW - QT-RR relation

KW - hypokalemia

KW - hypomagnesemia

KW - long QT syndrome

UR - http://www.scopus.com/inward/record.url?scp=84951310902&partnerID=8YFLogxK

U2 - 10.1016/j.jelectrocard.2015.10.002

DO - 10.1016/j.jelectrocard.2015.10.002

M3 - 学術論文

C2 - 26520166

AN - SCOPUS:84951310902

SN - 0022-0736

VL - 49

SP - 94

EP - 98

JO - Journal of Electrocardiology

JF - Journal of Electrocardiology

IS - 1

ER -

Abnormal repolarization dynamics in a patient with KCNE1 (G38S) who presented with torsades de pointes

Abstract

Keywords

ASJC Scopus subject areas

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