Molecular pathogenesis of familial encephalopathy with neuroserpin inclusion bodies

Research output

Research output per year 2006 2006 2007 2008 2009

• 26 Article
• 11 Presentation

Research output per year

Research output per year

Search results

• 2009

  Genomic organization of regions that regulate chicken glycine decarboxylase gene transcription: physiological and pathological implications

  H., K., Okamoto, S., Sikdar, D., Kume, A., F., L., Mohafez, O.M.M., Shehata, M.H., Hiraga, A. & K, 2009, In: Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. p. 7-18

  Research output: Contribution to journal › Article › peer-review
• 2008

  A novel mode1 of insulin-dependent diabetes with renal and retinal lesions by transgenic expression of CaMKIIα (Thr286Asp)in pancreatic β-cells.

  I., K., 2008, In: Diabetes Metab. Res. Rev. 24. p. 486-497

  Research output: Contribution to journal › Article › peer-review

• A novel model of insulin-dependent diabetes with renal and retinal lesions by transgenic expression of CaMKII (Thr286Asp) in pancreatic -cells. Diabetes Metab

  I., K., Oya, T., Suzuki, H., Takasawa, K., Ichsan, A.M., Nakada, S., Ishii, Y., Shimada, Y., Sasahara, M., Tobe, K. & Takasawa & 5 others, S., Okamoto, H., Hiraga & K, 2008, In: Diabetes Metab. Res. Rev. 24. p. 486-497

  Research output: Contribution to journal › Article › peer-review

• CCl_4障害肝に誘導されるガレクチ-3の役割

  川口博, 高畑正裕, 張鴻, 常山耕一, 鄭華川 & 平賀紘一, 2008.

  Research output: Contribution to conference › Presentation

• CCl_4障害肝に誘導されるガレクチン- 3の役割.

  川口 博, 2008.

  Research output: Contribution to conference › Presentation

• Galectin-3 is required for the process of insulin excretion from pancreatic β-cells.

  M. H., S., 2008.

  Research output: Contribution to conference › Presentation

• Glycine cleavage system:reaction mechanism, physiological significance, and hyperglycinemia

  Kikuchi & G., 2008, In: Proc.JPN Acad. Ser. B.

  Research output: Contribution to journal › Article › peer-review

• Glycine cleavage system : reaction mechanism, physiological significance, and hyperglycinemia

  Kikuchi, G., Motokawa, Y., Yoshida, T., Hiraga, A. & K, 2008, In: Proc. JPN. Acad., Ser. B 84. p. 246-263

  Research output: Contribution to journal › Article › peer-review

• Mutation-, aging-, and gene dosage-dependent accumulation of neuroserpin (G392E) in endoplasmic reticula and lysosomes of neurons in transgenic mice

  Takasawa, A., Kato, I., Takasawa, K., Ishii, Y., Yoshida, T., Shehata, M. H., Kawaguchi, H., Mohafez, O. M. M., Sasahara, M. & Hiraga, K., 2008/12/19, In: Journal of Biological Chemistry. 283, 51, p. 35606-35613 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Aging 100%
  • Endoplasmic Reticulum 100%
  • Lysosome 100%
  • Transgenic Mice 100%
  • Gene Dosage 100%
  21 Scopus citations

• Nonalcoholic steatohepatitis and hepatocellular carcinoma in galectin-3 knockout mice

  Nakanishi, Y., Tsuneyama, K., Nomoto, K., Fujimoto, M., Salunga, T. L., Nakajima, T., Miwa, S., Murai, Y., Hayashi, S., Kato, I., Hiraga, K., Hsu, D. K., Liu, F. T. & Takano, Y., 2008, In: Hepatology Research. 38, 12, p. 1241-1251 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Knock-in Mouse Model 100%
  • Nonalcoholic Steatohepatitis 100%
  • Hepatocellular Carcinoma 100%
  • Galectin-3 (Gal-3) 100%
  • Knockout Mouse 100%
  34 Scopus citations

• Novel transcript profiling of diffuse alveolar damage induced by hyperoxia exposure in mice: normalization by glyceraldehydes-3 phosphate dehydrogenase

  Shimada, I., Matsui, K., Brinkmann, B., Hoh, o.ff., .C., Hiraga, K., Tabuchi, Y., Takasaki, I., Kato, I., Kawaguchi, H. & Takasawa & 7 others, K., Iida, R., Takizawa, H., Matsuki & T, 2008, In: Int. J. Legal Med 122. p. 373-383

  Research output: Contribution to journal › Article › peer-review

• Targeted disruption of the galectin-3 gene results in decreased susceptibility to NNK-induced lung tumorigenesis: an oligonucleotide microarray studyJ

  H. O., A.-A., Murai, Y., Takasaki, I., Tabuchi, Y., Zheng, H-C., Nomoto, K., Takahashi, H., Tsuneyama, K., Kato, I., Hsu, D.K. & Liu & 5 others, F-T., Hiraga, K., Takano, A. & Y, 2008, In: J Cancer Res Clin Oncol. 134. p. 777-788

  Research output: Contribution to journal › Article › peer-review

• Targeted disruption of the galectin-3 gene results in decreased susceptibility to NNK-induced lung tumorisenesis : an oligonucleotide microarray study.

  H. O., A.-A., 2008, In: J Cancer Res Clin Oncol. 134. p. 777-788

  Research output: Contribution to journal › Article › peer-review

• Transgenic Mice overexpressing CaM KinaseII (T286D) in pancreatic beta cells have diabetic nephropathy with increased expression of PDGF-B chain.

  鈴木ひかり, 2008.

  Research output: Contribution to conference › Presentation

• インスリン分泌低下型糖尿病モデルマウスにおける糖尿病性腎症とPDGF経路についての検討.

  鈴木ひかり, 2008.

  Research output: Contribution to conference › Presentation

• 変異型CaM Kinase2(T286D)遺伝子導入マウスにおける重症糖尿病とその発症機序の解析.

  加藤一郎, 2008.

  Research output: Contribution to conference › Presentation

• 肝機能維持に必要なガレクチンー3作用機序の解明.

  川口 博, 2008.

  Research output: Contribution to conference › Presentation
• 2007

  A putative role of two tandem open reading frames in exon l of the mouse H-protein gene

  O., M., 2007.

  Research output: Contribution to conference › Presentation

• CD38 is critical for social behaviour by regulating oxytocin secretion.

  D., J., 2007, In: Nature (in press).

  Research output: Contribution to journal › Article › peer-review

• Connection between a dural artery and a dural vein in a dural arteriovenous fistula of the cranial vault - Case report

  Hori, E., Kuwayama, N., Harada, J., Kubo, M., Yamamoto, H. & Endo, S., 2007/01, In: Neurologia Medico-Chirurgica. 47, 1, p. 26-28 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dural Arteriovenous Fistula (dAVF) 100%
  • Dural 100%
  • Cranial Vault 100%
  • Hematoma 100%
  • Middle Meningeal Artery 100%
  5 Scopus citations

• Neuroprotective role of transgenic PAF-acetyl hydrolase II in mouse models of focal cerebral ischemia

  Umemura, K., Kato, I., Hirashima, Y., Ishii, Y., Inoue, T., Aoki, J., Kono, K., Oya, T., Hayashi, N., Hamada & H. & 10 others, Endo, S., Oda, M., Arai, H., Kinouchi, H., Hiraga, A. & K, 2007, In: Stroke 38(3). p. 1063-1068

  Research output: Contribution to journal › Article › peer-review

• Neuroprotective role of transgenic PAF-acetyl hydrolase ll in mouse models of focal cerebral ischemia

  Umemura & K., 2007, In: Stroke 38(3). p. 1063-1068

  Research output: Contribution to journal › Article › peer-review

• The mouse H-protein gene promoter is exonic

  O.M., M., 2007.

  Research output: Contribution to conference › Presentation

• Transcriptional modulation by nuclear matrix protein P130/MAT3 associated with MAR/SAR.

  Hibino, Y., Usui, T., Hiraga, &. & K, 2007, In: In Nuclear Dynamics, Nagata, K., & Takeyasu, K. eds. p. 255-262

  Research output: Contribution to journal › Article › peer-review

• 化学的障害肝で起こる情報伝達へのgalectin-3の果たす役割

  川口 博, 2007.

  Research output: Contribution to conference › Presentation

• 家族性早期発症型認知症FENIBモデルマウスにおいて変異型ニューロセルピン(G397E)は小胞体とリソゾームに蓄積する

  加藤一郎, 2007.

  Research output: Contribution to conference › Presentation
• 2006

  Disrupted galectin-3 causes non-alcoholic fatty liver disease in male mice

  Nomoto, K., Tsuneyama, K., Abdel Aziz, H. O., Takahashi, H., Murai, Y., Cui, Z. G., Fujimoto, M., Kato, I., Hiraga, K., Hsu, D. K., Liu, F. T. & Takano, Y., 2006/12, In: Journal of Pathology. 210, 4, p. 469-477 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Male Mice 100%
  • Non-alcoholic Fatty Liver Disease (NAFLD) 100%
  • Galectin-3 (Gal-3) 100%
  • Non-Alcoholic Fatty Liver Disease 100%
  • Galectin 3 100%
  61 Scopus citations

• Effect of arachnoid plasty using fibrin glue membrane after clipping of ruptured aneurysm on the occurrence of complications and outcome in the elderly patients.

  Y., M., 2006, In: Acta Neurochir.(Wien) 48. p. 627-631

  Research output: Contribution to journal › Article › peer-review

• Enzymatic and biochemical properties of a novel human serine dehydratase isoform

  Ogawa, H., Gomi, T., Nishizawa, M., Hayakawa, Y., Endo, S., Hayashi, K., Ochiai, H., Takusagawa, F., Pitot, H. C., Mori, H., Sakurai, H., Koizumi, K., Saiki, I., Oda, H., Fujishita, T., Miwa, T., Maruyama, M. & Kobayashi, M., 2006/05, In: Biochimica et Biophysica Acta - Proteins and Proteomics. 1764, 5, p. 961-971 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Biochemical Properties 100%
  • Enzymatic Properties 100%
  • D-Serine Dehydratase 100%
  • Isoform 100%
  • Dehydratase 100%
  9 Scopus citations

• Intracranial dural arteriovenous fistulas with retrograde cortical venous drainage: Assessment with cerebral blood volume by dynamic susceptibility contrast magnetic resonance imaging

  Noguchi, K., Kubo, M., Kuwayama, N., Kamisaki, Y., Tomizawa, G., Kameda, K., Kawabe, H., Ogawa, S., Watanabe, N., Endo, S. & Seto, H., 2006/06, In: American Journal of Neuroradiology. 27, 6, p. 1252-1256 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Intracranial Dural Arteriovenous Fistula 100%
  • Cortical Venous Drainage 100%
  • Dynamic Susceptibility Contrast Magnetic Resonance Imaging 100%
  • Relative Cerebral Blood Volume (rCBV) 100%
  • Cerebral Blood Volume 100%
  21 Scopus citations

• Neuronal responses to a delayed-response delayed-reward go/nogo task in the monkey posterior insular cortex

  Asahi, T., Uwano, T., Eifuku, S., Tamura, R., Endo, S., Ono, T. & Nishijo, H., 2006/12/01, In: Neuroscience. 143, 2, p. 627-639 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Monkey 100%
  • Neuronal Responses 100%
  • Delayed Response 100%
  • Nogo-A 100%
  • Insular Cortex 100%
  19 Scopus citations

• Neuroprotective role of transgenic PAF-acetylhydrolase II in mouse models of focal cerebral ischemia.

  K., U., 2006, In: Stroke 38(3). p. 1063-1068

  Research output: Contribution to journal › Article › peer-review

• Preparation and observation of fresh-frozen sections of the green fluorescent protein transgenic mouse head

  Tada, M., Shinohara, Y., Kato, I., Hiraga, K., Aizawa, T., Demura, M., Mori, Y., Shinoda, H., Mizuguchi, M. & Kawano, K., 2006, In: Acta Histochemica et Cytochemica. 39, 2, p. 31-34 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Transgenic Mice 100%
  • Green Fluorescent Protein 100%
  • Fresh Frozen Section 100%
  • Transgenic Mouse 100%
  • Frozen Section 100%
  4 Scopus citations

• RAGE control of diabetic nephropathy in a mouse model : effects of RAGE gene disruption and administration of low molecular weight heparin.

  K.M., M., 2006, In: Diabetes Care. p. 2510-2522

  Research output: Contribution to journal › Article › peer-review

• The galectin-3 gene promoter binding proteins in the liver of rats 48-h post-treatment with CCl4.

  F., L., 2006, In: Gene 367. p. 46-55

  Research output: Contribution to journal › Article › peer-review

• Transparent endoscopic sheath and rigid-rod endoscope used in endoscopic third ventriculostomy for hydrocephalus in the presence of deformed ventricular anatomy.

  N., H., 2006, In: J. Neurosurg 104. p. 321-325

  Research output: Contribution to journal › Article › peer-review

• Warning headache of subarachnoid hemorrhage and infarction due to vertebrobasilar artery dissection.

  T., S., 2006, In: Clin. J. Pain. 22. p. 193-196

  Research output: Contribution to journal › Article › peer-review