The role of serine protease granzyme on the induction of itch in atopic dermatitis

  • Andoh, Tsugunobu (Principal Investigator)
  • Kimura, Yusuke (Research Collaborator)

Project Details

Abstract

The precious mechanisms of itch in atopic dermatitis are unclear. Since T cells infiltrate into the skin with atopic dermatitis and the proteases are also involved in the severe itch, we focused proteases produced by T cells for demonstrating the itch mechanisms in the dermatitis. It was demonstrated that granzyme A, which is one of 11 subtypes of granzymes, elicited itch through the activation of proteinase-activated receptor 2
StatusFinished
Effective start/end date2010/01/01 → 2012/12/31

Funding

  • Japan Society for the Promotion of Science: ¥3,770,000.00

Keywords

  • 痒み
  • アトピー性皮膚炎
  • プロテアーゼ
  • グランザイム
  • 皮膚
  • NCマウス
  • T細胞
  • 掻き動作
  • プロテアーゼ活性化受容体

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