Pharmaceutical Therapy and Neuropharmacology

2024

Hippocampus-specific knockdown of Shati/Nat8l impairs cognitive function and electrophysiological response in mice

Izuo, N., Ikejima, D., Uno, K., Asano, T., Muramatsu, S. I. & Nitta, A., 2024/12/03, In: Biochemical and Biophysical Research Communications. 736, 150435.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Neuronal activation of nucleus accumbens by local methamphetamine administration induces cognitive impairment through microglial inflammation in mice

Kusui, Y., Izuo, N., Tokuhara, R., Asano, T. & Nitta, A., 2024/03, In: Journal of Pharmacological Sciences. 154, 3, p. 127-138 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Outer layer of Vb neurons in medial entorhinal cortex project to hippocampal dentate gyrus in mice

Yamamoto, N., Yokose, J., Ramesh, K., Kitamura, T. & Ogawa, S. K., 2024/12, In: Molecular Brain. 17, 1, 5.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Visuotactile integration facilitates mirror-induced self-directed behavior through activation of hippocampal neuronal ensembles in mice

Yokose, J., Marks, W. D. & Kitamura, T., 2024/01/17, In: Neuron. 112, 2, p. 306-318.e8

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

2023

Detection of Dietary Chalcone and Flavonoid Metabolites in Mice Using UPLC-MS/MS and Their Modulatory Effects on Amyloid β Aggregation

Taniwa, K., Murakami, K., Sakaguchi, Y., Izuo, N., Hanaki, M., Sampa, N., Kume, T., Shimizu, T. & Irie, K., 2023/10/04, In: Journal of Agricultural and Food Chemistry. 71, 39, p. 14289-14299 11 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Insulin resistance induces earlier initiation of cognitive dysfunction mediated by cholinergic deregulation in a mouse model of Alzheimer's disease

Izuo, N., Watanabe, N., Noda, Y., Saito, T., Saido, T. C., Yokote, K., Hotta, H. & Shimizu, T., 2023/11, In: Aging Cell. 22, 11, e13994.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Involvement of the Restoration of Cerebral Blood Flow and Maintenance of eNOS Expression in the Prophylactic Protective Effect of the Novel Ferulic Acid Derivative FAD012 against Ischemia/Reperfusion Injuries in Rats

Asano, T., Xuan, M., Iwata, N., Takayama, J., Hayashi, K., Kato, Y., Aoyama, T., Sugo, H., Matsuzaki, H., Yuan, B., Kamiuchi, S., Hibino, Y., Sakamoto, T. & Okazaki, M., 2023/06, In: International Journal of Molecular Sciences. 24, 11, 9663.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Optogenetic activation of dopamine D1 receptors in island cells of medial entorhinal cortex inhibits temporal association learning

Yokose, J., Yamamoto, N., Ogawa, S. K. & Kitamura, T., 2023/12, In: Molecular Brain. 16, 1, 78.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Sleep disturbance after cessation of cannabis administration in mice

Asano, T., Takemoto, H., Horita, T., Tokutake, T., Izuo, N., Mochizuki, T. & Nitta, A., 2023/12, In: Neuropsychopharmacology Reports. 43, 4, p. 505-512 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Systems consolidation induces multiple memory engrams for a flexible recall strategy in observational fear memory in male mice

Terranova, J. I., Yokose, J., Osanai, H., Ogawa, S. K. & Kitamura, T., 2023/12, In: Nature Communications. 14, 1, 3976.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

The Role of GABA in the Dorsal Striatum-Raphe Nucleus Circuit Regulating Stress Vulnerability in Male Mice with High Levels of Shati/Nat8l

Miyanishi, H., Suga, S., Sumi, K., Takakuwa, M., Izuo, N., Asano, T., Muramatsu, S. I. & Nitta, A., 2023/10, In: eNeuro. 10, 10

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Urinary levels of cortisol but not catecholamines are associated with those of 8-hydroxy-2'-deoxyguanosine in uncomplicated primary hypertension

Tomoda, F., Koike, T., Nitta, A., Kurosaki, H., Sugimori, H., Oh-Hara, M. & Kinugawa, K., 2023/10/01, In: Journal of hypertension. 41, 10, p. 1571-1577 7 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

2022

APP Knock-In Mice Produce E22P-Aβ Exhibiting an Alzheimer’s Disease-like Phenotype with Dysregulation of Hypoxia-Inducible Factor Expression

Maki, T., Sawahata, M., Akutsu, I., Amaike, S., Hiramatsu, G., Uta, D., Izuo, N., Shimizu, T., Irie, K. & Kume, T., 2022/11, In: International Journal of Molecular Sciences. 23, 21, 13259.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Cannabinoid Type 1 Receptors in the Basolateral Amygdala Regulate ACPA-Induced Place Preference and Anxiolytic-Like Behaviors

Tokutake, T., Asano, T., Miyanishi, H., Nakaya, S., Izuo, N. & Nitta, A., 2022/09, In: Neurochemical Research. 47, 9, p. 2899-2908 10 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Hippocampal-amygdala memory circuits govern experience-dependent observational fear

Terranova, J. I., Yokose, J., Osanai, H., Marks, W. D., Yamamoto, J., Ogawa, S. K. & Kitamura, T., 2022/04/20, In: Neuron. 110, 8, p. 1416-1431.e13

Research output: Contribution to journal › Article › peer-review

Open Access

58 Scopus citations

N-Acetyl Transferase, Shati/Nat8l, in the Dorsal Hippocampus Suppresses Aging-induced Impairment of Cognitive Function in Mice

Miyanishi, H., Kitazawa, A., Izuo, N., Muramatsu, S. I. & Nitta, A., 2022/09, In: Neurochemical Research. 47, 9, p. 2703-2714 12 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Plasma and Urinary Levels of Nerve Growth Factor Are Elevated in Primary Hypertension

Tomoda, F., Nitta, A., Sugimori, H., Koike, T. & Kinugawa, K., 2022, In: International Journal of Hypertension. 2022, 3003269.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Shati/Nat8l Overexpression Improves Cognitive Decline by Upregulating Neuronal Trophic Factor in Alzheimer’s Disease Model Mice

Chino, K., Izuo, N., Noike, H., Uno, K., Kuboyama, T., Tohda, C., Muramatsu, S. I. & Nitta, A., 2022/09, In: Neurochemical Research. 47, 9, p. 2805-2814 10 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

2021

Development of a novel alzheimer's disease model based on the theory of the toxic-conformer of amyloid β

Izuo, N., Shimizu, T., Murakami, K. & Irie, K., 2021/06/01, In: Yakugaku Zasshi. 141, 6, p. 843-849 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Shati/Nat8l deficiency disrupts adult neurogenesis and causes attentional impairment through dopaminergic neuronal dysfunction in the dentate gyrus

Wulaer, B., Kunisawa, K., Hada, K., Jaya Suento, W., Kubota, H., Iida, T., Kosuge, A., Nagai, T., Yamada, K., Nitta, A., Yamamoto, Y., Saito, K., Mouri, A. & Nabeshima, T., 2021/05, In: Journal of Neurochemistry. 157, 3, p. 642-655 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

2020

Investigating DNA methylation of SHATI/NAT8L promoter sites in blood of unmedicated patients with major depressive disorder

Miyanishi, H., Uno, K., Iwata, M., Kikuchi, Y., Yamamori, H., Yasuda, Y., Ohi, K., Hashimoto, R., Hattori, K., Yoshida, S., Goto, Y. I., Sumiyoshi, T. & Nitta, A., 2020/07/01, In: Biological and Pharmaceutical Bulletin. 43, 7, p. 1067-1072 6 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Synthetic and biophysical studies on the toxic conformer in amyloid β with the E22Δ mutation in Alzheimer pathology

Murakami, K., Irie, K., Yamaguchi, T., Izuo, N., Kume, T. & Hara, H., 2020/10/07, In: ACS Chemical Neuroscience. 11, 19, p. 3017-3024 8 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

2019

Dietary supplementation of a high-temperature-processed green tea extract attenuates cognitive impairment in PS2 and Tg2576 mice

Kim, J., Funayama, S., Izuo, N. & Shimizu, T., 2019, In: Bioscience, biotechnology, and biochemistry. 83, 12, p. 2364-2371 8 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health

Hofer, D. C., Zirkovits, G., Pelzmann, H. J., Huber, K., Pessentheiner, A. R., Xia, W., Uno, K., Miyazaki, T., Kon, K., Tsuneki, H., Pendl, T., Zoughbi, W. A., Madreiter-Sokolowski, C. T., Trausinger, G., Abdellatif, M., Schoiswohl, G., Schreiber, R., Eisenberg, T., Magnes, C. & Sedej, S. & 9 others, Eckhardt, M., Sasahara, M., Sasaoka, T., Nitta, A., Hoefler, G., Graier, W. F., Kratky, D., Auwerx, J. & Bogner-Strauss, J. G., 2019/12, In: FASEB Journal. 33, 12, p. 13808-13824 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Protective effect of green perilla-derived chalcone derivative DDC on amyloid β protein-induced neurotoxicity in primary cortical neurons

Iwasaki, M., Izuo, N., Izumi, Y., Takada-Takatori, Y., Akaike, A. & Kume, T., 2019, In: Biological and Pharmaceutical Bulletin. 42, 11, p. 1942-1946 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

2018

Shati/Nat8l knockout mice show behavioral deficits ameliorated by atomoxetine and methylphenidate

Toriumi, K., Tanaka, J., Mamiya, T., Alkam, T., Kim, H. C., Nitta, A. & Nabeshima, T., 2018/02/26, In: Behavioural Brain Research. 339, p. 207-214 8 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

2017

Behavioral impairment in SHATI/NAT8L knockout mice via dysfunction of myelination development

Sumi, K., Uno, K., Noike, H., Tomohiro, T., Hatanaka, Y., Furukawa-Hibi, Y., Nabeshima, T., Miyamoto, Y. & Nitta, A., 2017/12/01, In: Scientific Reports. 7, 1, 16872.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Involvement of the accumbal osteopontin-interacting transmembrane protein 168 in methamphetamine-induced place preference and hyperlocomotion in mice

Fu, K., Miyamoto, Y., Otake, K., Sumi, K., Saika, E., Matsumura, S., Sato, N., Ueno, Y., Seo, S., Uno, K., Muramatsu, S. I. & Nitta, A., 2017/12/01, In: Scientific Reports. 7, 1, 13084.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Methamphetamine induces Shati/Nat8L expression in the mouse nucleus accumbens via CREB- and dopamine D1 receptor-dependent mechanism

Uno, K., Miyazaki, T., Sodeyama, K., Miyamoto, Y. & Nitta, A., 2017/03, In: PLoS ONE. 12, 3, e0174196.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Overexpression of transmembrane protein 168 in the mouse nucleus accumbens induces anxiety and sensorimotor gating deficit

Fu, K., Miyamoto, Y., Sumi, K., Saika, E., Muramatsu, S. I., Uno, K. & Nitta, A., 2017/12, In: PLoS ONE. 12, 12, e0189006.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Overlapping memory trace indispensable for linking, but not recalling, individual memories

Yokose, J., Suzuki, R., Nomoto, M., Ohkawa, N., Nishizono, H., Suzuki, A., Matsuo, M., Tsujimura, S., Takahashi, Y., Nagase, M., Watabe, A. M., Sasahara, M., Kato, F. & Inokuchi, K., 2017/01/27, In: Science. 355, 6323, p. 398-403 6 p.

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Striatal n-acetylaspartate synthetase Shati/Nat8l regulates depression-like behaviors via mGluR3-mediated serotonergic suppression in mice

Miyamoto, Y., Iegaki, N., Fu, K., Ishikawa, Y., Sumi, K., Azuma, S., Uno, K., Muramatsu, S. I. & Nitta, A., 2017/12/01, In: International Journal of Neuropsychopharmacology. 20, 12, p. 1027-1035 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

The involvement of brain-derived neurotrophic factor in 3,4-methylenedioxymethamphetamine-induced place preference and behavioral sensitization

Mouri, A., Noda, Y., Niwa, M., Matsumoto, Y., Mamiya, T., Nitta, A., Yamada, K., Furukawa, S., Iwamura, T. & Nabeshima, T., 2017/06/30, In: Behavioural Brain Research. 329, p. 157-165 9 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

2016

Analysis of pharmacist-patient communication using the Roter Method of Interaction Process Analysis System

Nakayama, C., Kimata, S., Oshima, T., Kato, A. & Nitta, A., 2016, In: Research in Social and Administrative Pharmacy. 12, 2, p. 319-326 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Cellular tagging as a neural network mechanism for behavioural tagging

Nomoto, M., Ohkawa, N., Nishizono, H., Yokose, J., Suzuki, A., Matsuo, M., Tsujimura, S., Takahashi, Y., Nagase, M., Watabe, A. M., Kato, F. & Inokuchi, K., 2016/11/25, In: Nature Communications. 7, 1, 12319.

Research output: Contribution to journal › Article › peer-review

Open Access

74 Scopus citations

Decreased DNA methylation in the Shati/Nat8l promoter in both patients with schizophrenia and a methamphetamine-induced Murine model of schizophrenia-like phenotype

Uno, K., Kikuchi, Y., Iwata, M., Uehara, T., Matsuoka, T., Sumiyoshi, T., Okamoto, Y., Jinno, H., Takada, T., Furukawa-Hibi, Y., Nabeshima, T., Miyamoto, Y. & Nitta, A., 2016/06, In: PLoS ONE. 11, 6, e0157959.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Pseudoginsenoside-F₁₁ inhibits methamphetamine-induced behaviors by regulating dopaminergic and GABAergic neurons in the nucleus accumbens

Fu, K., Lin, H., Miyamoto, Y., Wu, C., Yang, J., Uno, K. & Nitta, A., 2016/03/01, In: Psychopharmacology. 233, 5, p. 831-840 10 p.

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

2015

Deletion of SHATI/NAT8L decreases the N-acetylaspartate content in the brain and induces behavioral deficits, which can be ameliorated by administering N-acetylaspartate

Toriumi, K., Mamiya, T., Song, Z., Honjo, T., Watanabe, H., Tanaka, J., Kondo, M., Mouri, A., Kim, H. C., Nitta, A., Fukushima, T. & Nabeshima, T., 2015/11, In: European Neuropsychopharmacology. 25, 11, p. 2108-2117 10 p.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Induction of neuronal axon outgrowth by Shati/Nat8l by energy metabolism in mice cultured neurons

Sumi, K., Uno, K., Matsumura, S., Miyamoto, Y., Furukawa-Hibi, Y., Muramatsu, S. I., Nabeshima, T. & Nitta, A., 2015/08/19, In: NeuroReport. 26, 13, p. 740-746 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Pubertal administration of antiserum against nerve growth factor regresses renal vascular remodeling in spontaneously hypertensive rats

Ohara, M., Tomoda, F., Koike, T., Liu, H., Uno, K., Nitta, A. & Inoue, H., 2015/06/01, In: Clinical and Experimental Pharmacology and Physiology. 42, 6, p. 687-694 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Stability of octreotide acetate decreases in a sodium bisulfate concentration-dependent manner: Compatibility study with morphine and metoclopramide injections

Tanabe, K., Wada, J., Ohkubo, J., Nitta, A., Ikezaki, T., Takeuchi, M., Handa, A., Tanaka, M., Murakami, N., Kashii, T. & Kitazawa, H., 2015/05, In: European Journal of Hospital Pharmacy. 22, 3, p. 171-175 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

The piccolo intronic single nucleotide polymorphism rs13438494 regulates dopamine and serotonin uptake and shows associations with dependence-like behavior in genomic association study

Uno, K., Nishizawa, D., Seo, S., Takayama, K., Matsumura, S., Sakai, N., Ohi, K., Nabeshima, T., Hashimoto, R., Ozaki, N., Hasegawa, J., Sato, N., Tanioka, F., Sugimura, H., Fukuda, K. I., Higuchi, S., Ujike, H., Inada, T., Iwata, N. & Sora, I. & 10 others, Iyo, M., Kondo, N., Won, M. J., Naruse, N., Uehara-Aoyama, K., Itokawa, M., Yamada, M., Ikeda, K., Miyamoto, Y. & Nitta, A., 2015/05/01, In: Current Molecular Medicine. 15, 3, p. 265-274 10 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

2014

Overexpression of Shati/Nat8l, an N-acetyltransferase, in the nucleus accumbens attenuates the response to methamphetamine via activation of group II mGluRs in mice

Miyamoto, Y., Ishikawa, Y., Iegaki, N., Sumi, K., Fu, K., Sato, K., Furukawa-Hibi, Y., Muramatsu, S. I., Nabeshima, T., Uno, K. & Nitta, A., 2014/08/20, In: International Journal of Neuropsychopharmacology. 17, 8, p. 1283-1294 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

2013

Functional Analysis of Deep Intronic SNP rs13438494 in Intron 24 of PCLO Gene

Seo, S., Takayama, K., Uno, K., Ohi, K., Hashimoto, R., Nishizawa, D., Ikeda, K., Ozaki, N., Nabeshima, T., Miyamoto, Y. & Nitta, A., 2013/10/22, In: PLoS ONE. 8, 10, e76960.

Research output: Contribution to journal › Article › peer-review

Open Access

51 Scopus citations

Intrastriatal gene delivery of GDNF persistently attenuates methamphetamine self-administration and relapse in mice

Yan, Y., Miyamoto, Y., Nitta, A., Muramatsu, S. I., Ozawa, K., Yamada, K. & Nabeshima, T., 2013/08, In: International Journal of Neuropsychopharmacology. 16, 7, p. 1559-1567 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

NAT8L (N-acetyltransferase 8-like) accelerates lipid turnover and increases energy expenditure in brown adipocytes

Pessentheiner, A. R., Pelzmann, H. J., Walenta, E., Schweiger, M., Groschner, L. N., Graier, W. F., Kolb, D., Uno, K., Miyazaki, T., Nitta, A., Rieder, D., Prokesch, A. & Bogner-Strauss, J. G., 2013/12/13, In: Journal of Biological Chemistry. 288, 50, p. 36040-36051 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

62 Scopus citations

SHATI/NAT8L regulates neurite outgrowth via microtubule stabilization

Toriumi, K., Ikami, M., Kondo, M., Mouri, A., Koseki, T., Ibi, D., Furukawa-Hibi, Y., Nagai, T., Mamiya, T., Nitta, A., Yamada, K. & Nabeshima, T., 2013/12, In: Journal of Neuroscience Research. 91, 12, p. 1525-1532 8 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

2011

Heparin-binding EGF-like growth factor is required for synaptic plasticity and memory formation

Oyagi, A., Moriguchi, S., Nitta, A., Murata, K., Oida, Y., Tsuruma, K., Shimazawa, M., Fukunaga, K. & Hara, H., 2011/10/24, In: Brain Research. 1419, p. 97-104 8 p.

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Periocular injection of in situ hydrogels containing Leu-Ile, an inducer for neurotrophic factors, promotes retinal ganglion cell survival after optic nerve injury

Nakatani, M., Shinohara, Y., Takii, M., Mori, H., Asai, N., Nishimura, S., Furukawa-Hibi, Y., Miyamoto, Y. & Nitta, A., 2011/12, In: Experimental Eye Research. 93, 6, p. 873-879 7 p.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

2010

Chronic restraint stress impairs neurogenesis and hippocampus-dependent fear memory in mice: Possible involvement of a brain-specific transcription factor Npas4

Yun, J., Koike, H., Ibi, D., Toth, E., Mizoguchi, H., Nitta, A., Yoneyama, M., Ogita, K., Yoneda, Y., Nabeshima, T., Nagai, T. & Yamada, K., 2010/09, In: Journal of Neurochemistry. 114, 6, p. 1840-1851 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

125 Scopus citations

Pharmaceutical Therapy and Neuropharmacology

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