Xylogranin B: A potent Wnt signal inhibitory limonoid from Xylocarpus granatum

Kazufumi Toume; Kentaro Kamiya; Midori A. Arai; Naomi Mori; Samir K. Sadhu; Firoj Ahmed; Masami Ishibashi

doi:10.1021/ol4029995

Xylogranin B: A potent Wnt signal inhibitory limonoid from Xylocarpus granatum

Kazufumi Toume, Kentaro Kamiya, Midori A. Arai, Naomi Mori, Samir K. Sadhu, Firoj Ahmed, Masami Ishibashi^*

^*この論文の責任著者

和漢医薬学総合研究所薬用資源管理部門

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

36 被引用数 (Scopus)

抄録

Xylogranin B (2) was isolated from Xylocarpus granatum (Meliaceae) leaves, by use of a cell-based luciferase screening system targeting a Wnt signaling pathway. Compound 2 inhibited TCF/β-catenin transcriptional activity (IC₅₀ 48.9 nM) and exhibited strong cytotoxicity against colon cancer cell lines. Compound 2 significantly decreased β-catenin protein levels in nuclei but not in the cytosol. These results indicated that a decrease in β-catenin levels in nuclei by 2 resulted in the Wnt signal inhibitory effects of 2.

本文言語	英語
ページ（範囲）	6106-6109
ページ数	4
ジャーナル	Organic Letters
巻	15
号	23
DOI	https://doi.org/10.1021/ol4029995
出版ステータス	出版済み - 2013/12/06

ASJC Scopus 主題領域

生化学
物理化学および理論化学
有機化学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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10.1021/ol4029995

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title = "Xylogranin B: A potent Wnt signal inhibitory limonoid from Xylocarpus granatum",

abstract = "Xylogranin B (2) was isolated from Xylocarpus granatum (Meliaceae) leaves, by use of a cell-based luciferase screening system targeting a Wnt signaling pathway. Compound 2 inhibited TCF/β-catenin transcriptional activity (IC50 48.9 nM) and exhibited strong cytotoxicity against colon cancer cell lines. Compound 2 significantly decreased β-catenin protein levels in nuclei but not in the cytosol. These results indicated that a decrease in β-catenin levels in nuclei by 2 resulted in the Wnt signal inhibitory effects of 2.",

author = "Kazufumi Toume and Kentaro Kamiya and Arai, {Midori A.} and Naomi Mori and Sadhu, {Samir K.} and Firoj Ahmed and Masami Ishibashi",

year = "2013",

month = dec,

day = "6",

doi = "10.1021/ol4029995",

language = "英語",

volume = "15",

pages = "6106--6109",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

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TY - JOUR

T1 - Xylogranin B

T2 - A potent Wnt signal inhibitory limonoid from Xylocarpus granatum

AU - Toume, Kazufumi

AU - Kamiya, Kentaro

AU - Arai, Midori A.

AU - Mori, Naomi

AU - Sadhu, Samir K.

AU - Ahmed, Firoj

AU - Ishibashi, Masami

PY - 2013/12/6

Y1 - 2013/12/6

N2 - Xylogranin B (2) was isolated from Xylocarpus granatum (Meliaceae) leaves, by use of a cell-based luciferase screening system targeting a Wnt signaling pathway. Compound 2 inhibited TCF/β-catenin transcriptional activity (IC50 48.9 nM) and exhibited strong cytotoxicity against colon cancer cell lines. Compound 2 significantly decreased β-catenin protein levels in nuclei but not in the cytosol. These results indicated that a decrease in β-catenin levels in nuclei by 2 resulted in the Wnt signal inhibitory effects of 2.

AB - Xylogranin B (2) was isolated from Xylocarpus granatum (Meliaceae) leaves, by use of a cell-based luciferase screening system targeting a Wnt signaling pathway. Compound 2 inhibited TCF/β-catenin transcriptional activity (IC50 48.9 nM) and exhibited strong cytotoxicity against colon cancer cell lines. Compound 2 significantly decreased β-catenin protein levels in nuclei but not in the cytosol. These results indicated that a decrease in β-catenin levels in nuclei by 2 resulted in the Wnt signal inhibitory effects of 2.

UR - http://www.scopus.com/inward/record.url?scp=84890068524&partnerID=8YFLogxK

U2 - 10.1021/ol4029995

DO - 10.1021/ol4029995

M3 - 学術論文

C2 - 24255943

AN - SCOPUS:84890068524

SN - 1523-7060

VL - 15

SP - 6106

EP - 6109

JO - Organic Letters

JF - Organic Letters

IS - 23

ER -

Xylogranin B: A potent Wnt signal inhibitory limonoid from Xylocarpus granatum

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ASJC Scopus 主題領域

UN SDG

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