Xylogranin B: A potent Wnt signal inhibitory limonoid from Xylocarpus granatum

Kazufumi Toume; Kentaro Kamiya; Midori A. Arai; Naomi Mori; Samir K. Sadhu; Firoj Ahmed; Masami Ishibashi

doi:10.1021/ol4029995

Xylogranin B: A potent Wnt signal inhibitory limonoid from Xylocarpus granatum

Kazufumi Toume, Kentaro Kamiya, Midori A. Arai, Naomi Mori, Samir K. Sadhu, Firoj Ahmed, Masami Ishibashi^*

^*Corresponding author for this work

Department of Medicinal Resources Management, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Xylogranin B (2) was isolated from Xylocarpus granatum (Meliaceae) leaves, by use of a cell-based luciferase screening system targeting a Wnt signaling pathway. Compound 2 inhibited TCF/β-catenin transcriptional activity (IC₅₀ 48.9 nM) and exhibited strong cytotoxicity against colon cancer cell lines. Compound 2 significantly decreased β-catenin protein levels in nuclei but not in the cytosol. These results indicated that a decrease in β-catenin levels in nuclei by 2 resulted in the Wnt signal inhibitory effects of 2.

Original language	English
Pages (from-to)	6106-6109
Number of pages	4
Journal	Organic Letters
Volume	15
Issue number	23
DOIs	https://doi.org/10.1021/ol4029995
State	Published - 2013/12/06

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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title = "Xylogranin B: A potent Wnt signal inhibitory limonoid from Xylocarpus granatum",

abstract = "Xylogranin B (2) was isolated from Xylocarpus granatum (Meliaceae) leaves, by use of a cell-based luciferase screening system targeting a Wnt signaling pathway. Compound 2 inhibited TCF/β-catenin transcriptional activity (IC50 48.9 nM) and exhibited strong cytotoxicity against colon cancer cell lines. Compound 2 significantly decreased β-catenin protein levels in nuclei but not in the cytosol. These results indicated that a decrease in β-catenin levels in nuclei by 2 resulted in the Wnt signal inhibitory effects of 2.",

author = "Kazufumi Toume and Kentaro Kamiya and Arai, {Midori A.} and Naomi Mori and Sadhu, {Samir K.} and Firoj Ahmed and Masami Ishibashi",

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doi = "10.1021/ol4029995",

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T1 - Xylogranin B

T2 - A potent Wnt signal inhibitory limonoid from Xylocarpus granatum

AU - Toume, Kazufumi

AU - Kamiya, Kentaro

AU - Arai, Midori A.

AU - Mori, Naomi

AU - Sadhu, Samir K.

AU - Ahmed, Firoj

AU - Ishibashi, Masami

PY - 2013/12/6

Y1 - 2013/12/6

N2 - Xylogranin B (2) was isolated from Xylocarpus granatum (Meliaceae) leaves, by use of a cell-based luciferase screening system targeting a Wnt signaling pathway. Compound 2 inhibited TCF/β-catenin transcriptional activity (IC50 48.9 nM) and exhibited strong cytotoxicity against colon cancer cell lines. Compound 2 significantly decreased β-catenin protein levels in nuclei but not in the cytosol. These results indicated that a decrease in β-catenin levels in nuclei by 2 resulted in the Wnt signal inhibitory effects of 2.

AB - Xylogranin B (2) was isolated from Xylocarpus granatum (Meliaceae) leaves, by use of a cell-based luciferase screening system targeting a Wnt signaling pathway. Compound 2 inhibited TCF/β-catenin transcriptional activity (IC50 48.9 nM) and exhibited strong cytotoxicity against colon cancer cell lines. Compound 2 significantly decreased β-catenin protein levels in nuclei but not in the cytosol. These results indicated that a decrease in β-catenin levels in nuclei by 2 resulted in the Wnt signal inhibitory effects of 2.

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JO - Organic Letters

JF - Organic Letters

IS - 23

ER -

Xylogranin B: A potent Wnt signal inhibitory limonoid from Xylocarpus granatum

Abstract

ASJC Scopus subject areas

UN SDGs

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