Water-soluble porphyrinoids as G-quadruplex binders and telomerase inhibitors

Yoshiya Ikawa; Sho Katsumata; Ryuichi Sakashita; Shinobu Sato; Shigeori Takenaka; Hiroyuki Furuta

doi:10.1142/S108842461650053X

Water-soluble porphyrinoids as G-quadruplex binders and telomerase inhibitors

Yoshiya Ikawa, Sho Katsumata, Ryuichi Sakashita, Shinobu Sato, Shigeori Takenaka, Hiroyuki Furuta^*

^*この論文の責任著者

化学科

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

4 被引用数 (Scopus)

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Water-soluble derivatives of three kinds of expanded porphyrins (N-fused pentaphyrin, hexaphyrin, and heptaphyrin) were synthesized and their binding ability to G-quadruplex (G4-) DNA and the inhibitory effects on enzymatic telomere extension were investigated. While expanded porphyrins increased the melting temperature of G4-DNA more effectively than the regular porphyrins, a porphyrin isomer (N-confused porphyrin) showed the highest inhibitory effect on telomerase activity.

本文言語	英語
ページ（範囲）	1041-1048
ページ数	8
ジャーナル	Journal of Porphyrins and Phthalocyanines
巻	20
号	8-11
DOI	https://doi.org/10.1142/S108842461650053X
出版ステータス	出版済み - 2016/08/01

ASJC Scopus 主題領域

化学一般

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10.1142/S108842461650053X

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title = "Water-soluble porphyrinoids as G-quadruplex binders and telomerase inhibitors",

abstract = "Water-soluble derivatives of three kinds of expanded porphyrins (N-fused pentaphyrin, hexaphyrin, and heptaphyrin) were synthesized and their binding ability to G-quadruplex (G4-) DNA and the inhibitory effects on enzymatic telomere extension were investigated. While expanded porphyrins increased the melting temperature of G4-DNA more effectively than the regular porphyrins, a porphyrin isomer (N-confused porphyrin) showed the highest inhibitory effect on telomerase activity.",

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author = "Yoshiya Ikawa and Sho Katsumata and Ryuichi Sakashita and Shinobu Sato and Shigeori Takenaka and Hiroyuki Furuta",

note = "Publisher Copyright: {\textcopyright} 2016 World Scientific Publishing Company.",

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doi = "10.1142/S108842461650053X",

language = "英語",

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T1 - Water-soluble porphyrinoids as G-quadruplex binders and telomerase inhibitors

AU - Ikawa, Yoshiya

AU - Katsumata, Sho

AU - Sakashita, Ryuichi

AU - Sato, Shinobu

AU - Takenaka, Shigeori

AU - Furuta, Hiroyuki

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Water-soluble derivatives of three kinds of expanded porphyrins (N-fused pentaphyrin, hexaphyrin, and heptaphyrin) were synthesized and their binding ability to G-quadruplex (G4-) DNA and the inhibitory effects on enzymatic telomere extension were investigated. While expanded porphyrins increased the melting temperature of G4-DNA more effectively than the regular porphyrins, a porphyrin isomer (N-confused porphyrin) showed the highest inhibitory effect on telomerase activity.

AB - Water-soluble derivatives of three kinds of expanded porphyrins (N-fused pentaphyrin, hexaphyrin, and heptaphyrin) were synthesized and their binding ability to G-quadruplex (G4-) DNA and the inhibitory effects on enzymatic telomere extension were investigated. While expanded porphyrins increased the melting temperature of G4-DNA more effectively than the regular porphyrins, a porphyrin isomer (N-confused porphyrin) showed the highest inhibitory effect on telomerase activity.

KW - G-quadruplex

KW - N-confused porphyrin

KW - telomerase inhibitor

KW - water-soluble expanded porphyrin

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M3 - 学術論文

AN - SCOPUS:84980318049

SN - 1088-4246

VL - 20

SP - 1041

EP - 1048

JO - Journal of Porphyrins and Phthalocyanines

JF - Journal of Porphyrins and Phthalocyanines

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ER -

Water-soluble porphyrinoids as G-quadruplex binders and telomerase inhibitors

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