TY - JOUR
T1 - Thrombotic thrombocytopenic purpura caused by piperacillin successfully treated with plasma infusion
AU - Yata, Y.
AU - Miyagiwa, M.
AU - Inatsuchi, S.
AU - Hiraiwa, Y.
AU - Murakami, J.
AU - Kato, T.
AU - Takahara, T.
AU - Watanabe, A.
PY - 2000
Y1 - 2000
N2 - An 81-year-old man was admitted to the hospital with a fever and loss of appetite. After treatment with piperacillin sodium (PIPC), the patient exhibited thrombocytopenia, hemorrhagic colitis, and drug-induced skin eruption. On the fifth day after PIPC induction, he further experienced neurological abnormalities, such as disorientation and confusion, renal dysfunction, and microangiopathic hemolytic anemia (MAHA). The patient was diagnosed with thrombotic thrombocytopenic purpura (TTP) on the basis of thrombocytopenia, MAHA, renal dysfunction, fever, and neurological abnormalities. Infusion of fresh-frozen plasma was initiated for treatment. His condition improved markedly after this treatment. It is rare for TTP to be accompanied with hemorrhagic colitis and skin eruption. These symptoms were induced by PIPC and were successfully treated with plasma infusion.
AB - An 81-year-old man was admitted to the hospital with a fever and loss of appetite. After treatment with piperacillin sodium (PIPC), the patient exhibited thrombocytopenia, hemorrhagic colitis, and drug-induced skin eruption. On the fifth day after PIPC induction, he further experienced neurological abnormalities, such as disorientation and confusion, renal dysfunction, and microangiopathic hemolytic anemia (MAHA). The patient was diagnosed with thrombotic thrombocytopenic purpura (TTP) on the basis of thrombocytopenia, MAHA, renal dysfunction, fever, and neurological abnormalities. Infusion of fresh-frozen plasma was initiated for treatment. His condition improved markedly after this treatment. It is rare for TTP to be accompanied with hemorrhagic colitis and skin eruption. These symptoms were induced by PIPC and were successfully treated with plasma infusion.
KW - Antibiotics
KW - Drug eruption
KW - Drug-induced colitis
KW - Plasma infusion
KW - Thrombotic thrombocytopenic purpura
UR - http://www.scopus.com/inward/record.url?scp=0033623594&partnerID=8YFLogxK
U2 - 10.1007/s002770000195
DO - 10.1007/s002770000195
M3 - 学術論文
C2 - 11100754
AN - SCOPUS:0033623594
SN - 0939-5555
VL - 79
SP - 593
EP - 595
JO - Annals of Hematology
JF - Annals of Hematology
IS - 10
ER -