Thrombotic thrombocytopenic purpura caused by piperacillin successfully treated with plasma infusion

Y. Yata; M. Miyagiwa; S. Inatsuchi; Y. Hiraiwa; J. Murakami; T. Kato; T. Takahara; A. Watanabe

doi:10.1007/s002770000195

Thrombotic thrombocytopenic purpura caused by piperacillin successfully treated with plasma infusion

Y. Yata^*, M. Miyagiwa, S. Inatsuchi, Y. Hiraiwa, J. Murakami, T. Kato, T. Takahara, A. Watanabe

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

An 81-year-old man was admitted to the hospital with a fever and loss of appetite. After treatment with piperacillin sodium (PIPC), the patient exhibited thrombocytopenia, hemorrhagic colitis, and drug-induced skin eruption. On the fifth day after PIPC induction, he further experienced neurological abnormalities, such as disorientation and confusion, renal dysfunction, and microangiopathic hemolytic anemia (MAHA). The patient was diagnosed with thrombotic thrombocytopenic purpura (TTP) on the basis of thrombocytopenia, MAHA, renal dysfunction, fever, and neurological abnormalities. Infusion of fresh-frozen plasma was initiated for treatment. His condition improved markedly after this treatment. It is rare for TTP to be accompanied with hemorrhagic colitis and skin eruption. These symptoms were induced by PIPC and were successfully treated with plasma infusion.

Original language	English
Pages (from-to)	593-595
Number of pages	3
Journal	Annals of Hematology
Volume	79
Issue number	10
DOIs	https://doi.org/10.1007/s002770000195
State	Published - 2000

Keywords

Antibiotics
Drug eruption
Drug-induced colitis
Plasma infusion
Thrombotic thrombocytopenic purpura

ASJC Scopus subject areas

Hematology

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10.1007/s002770000195

Cite this

@article{06361118833a4aaab6c79090025a370a,

title = "Thrombotic thrombocytopenic purpura caused by piperacillin successfully treated with plasma infusion",

abstract = "An 81-year-old man was admitted to the hospital with a fever and loss of appetite. After treatment with piperacillin sodium (PIPC), the patient exhibited thrombocytopenia, hemorrhagic colitis, and drug-induced skin eruption. On the fifth day after PIPC induction, he further experienced neurological abnormalities, such as disorientation and confusion, renal dysfunction, and microangiopathic hemolytic anemia (MAHA). The patient was diagnosed with thrombotic thrombocytopenic purpura (TTP) on the basis of thrombocytopenia, MAHA, renal dysfunction, fever, and neurological abnormalities. Infusion of fresh-frozen plasma was initiated for treatment. His condition improved markedly after this treatment. It is rare for TTP to be accompanied with hemorrhagic colitis and skin eruption. These symptoms were induced by PIPC and were successfully treated with plasma infusion.",

keywords = "Antibiotics, Drug eruption, Drug-induced colitis, Plasma infusion, Thrombotic thrombocytopenic purpura",

author = "Y. Yata and M. Miyagiwa and S. Inatsuchi and Y. Hiraiwa and J. Murakami and T. Kato and T. Takahara and A. Watanabe",

year = "2000",

doi = "10.1007/s002770000195",

language = "英語",

volume = "79",

pages = "593--595",

journal = "Annals of Hematology",

issn = "0939-5555",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "10",

}

TY - JOUR

T1 - Thrombotic thrombocytopenic purpura caused by piperacillin successfully treated with plasma infusion

AU - Yata, Y.

AU - Miyagiwa, M.

AU - Inatsuchi, S.

AU - Hiraiwa, Y.

AU - Murakami, J.

AU - Kato, T.

AU - Takahara, T.

AU - Watanabe, A.

PY - 2000

Y1 - 2000

N2 - An 81-year-old man was admitted to the hospital with a fever and loss of appetite. After treatment with piperacillin sodium (PIPC), the patient exhibited thrombocytopenia, hemorrhagic colitis, and drug-induced skin eruption. On the fifth day after PIPC induction, he further experienced neurological abnormalities, such as disorientation and confusion, renal dysfunction, and microangiopathic hemolytic anemia (MAHA). The patient was diagnosed with thrombotic thrombocytopenic purpura (TTP) on the basis of thrombocytopenia, MAHA, renal dysfunction, fever, and neurological abnormalities. Infusion of fresh-frozen plasma was initiated for treatment. His condition improved markedly after this treatment. It is rare for TTP to be accompanied with hemorrhagic colitis and skin eruption. These symptoms were induced by PIPC and were successfully treated with plasma infusion.

AB - An 81-year-old man was admitted to the hospital with a fever and loss of appetite. After treatment with piperacillin sodium (PIPC), the patient exhibited thrombocytopenia, hemorrhagic colitis, and drug-induced skin eruption. On the fifth day after PIPC induction, he further experienced neurological abnormalities, such as disorientation and confusion, renal dysfunction, and microangiopathic hemolytic anemia (MAHA). The patient was diagnosed with thrombotic thrombocytopenic purpura (TTP) on the basis of thrombocytopenia, MAHA, renal dysfunction, fever, and neurological abnormalities. Infusion of fresh-frozen plasma was initiated for treatment. His condition improved markedly after this treatment. It is rare for TTP to be accompanied with hemorrhagic colitis and skin eruption. These symptoms were induced by PIPC and were successfully treated with plasma infusion.

KW - Antibiotics

KW - Drug eruption

KW - Drug-induced colitis

KW - Plasma infusion

KW - Thrombotic thrombocytopenic purpura

UR - http://www.scopus.com/inward/record.url?scp=0033623594&partnerID=8YFLogxK

U2 - 10.1007/s002770000195

DO - 10.1007/s002770000195

M3 - 学術論文

C2 - 11100754

AN - SCOPUS:0033623594

SN - 0939-5555

VL - 79

SP - 593

EP - 595

JO - Annals of Hematology

JF - Annals of Hematology

IS - 10

ER -

Thrombotic thrombocytopenic purpura caused by piperacillin successfully treated with plasma infusion

Abstract

Keywords

ASJC Scopus subject areas

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