Three new lignans, longipedunins A-C, from Kadsura longipedunculata and their inhibitory activity against HIV-1 protease

Quan Zhong Sun; Dao Feng Chen; Pei Lan Ding; Chao Mei Ma; Hiroko Kakuda; Norio Nakamura; Masao Hattori

doi:10.1248/cpb.54.129

Three new lignans, longipedunins A-C, from Kadsura longipedunculata and their inhibitory activity against HIV-1 protease

Quan Zhong Sun, Dao Feng Chen, Pei Lan Ding, Chao Mei Ma, Hiroko Kakuda, Norio Nakamura, Masao Hattori^*

^*この論文の責任著者

教養教育学系

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

39 被引用数 (Scopus)

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Three new lignans, longipedunins A (1), B (2) and C (3), together with three known compounds, benzoyl-binankadsurin A (4), acetyl-binankadsurin A (5) and schisanlactone A (6), were isolated from Kadsura longipedunculata. Their structures and stereochemistry were determined by spectral and single-crystal X-ray analyses. Compounds 1 and 6 showed appreciable inhibitory activity against HIV-1 protease with IC₅₀ values of 50 and 20 μM, respectively.

本文言語	英語
ページ（範囲）	129-132
ページ数	4
ジャーナル	Chemical and Pharmaceutical Bulletin
巻	54
号	1
DOI	https://doi.org/10.1248/cpb.54.129
出版ステータス	出版済み - 2006/01

ASJC Scopus 主題領域

化学一般
創薬

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10.1248/cpb.54.129

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abstract = "Three new lignans, longipedunins A (1), B (2) and C (3), together with three known compounds, benzoyl-binankadsurin A (4), acetyl-binankadsurin A (5) and schisanlactone A (6), were isolated from Kadsura longipedunculata. Their structures and stereochemistry were determined by spectral and single-crystal X-ray analyses. Compounds 1 and 6 showed appreciable inhibitory activity against HIV-1 protease with IC50 values of 50 and 20 μM, respectively.",

keywords = "HIV-1 protease, Kadsura longipedunculata, Lignan, Longipedunin, X-ray crystal structure",

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AU - Sun, Quan Zhong

AU - Chen, Dao Feng

AU - Ding, Pei Lan

AU - Ma, Chao Mei

AU - Kakuda, Hiroko

AU - Nakamura, Norio

AU - Hattori, Masao

PY - 2006/1

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N2 - Three new lignans, longipedunins A (1), B (2) and C (3), together with three known compounds, benzoyl-binankadsurin A (4), acetyl-binankadsurin A (5) and schisanlactone A (6), were isolated from Kadsura longipedunculata. Their structures and stereochemistry were determined by spectral and single-crystal X-ray analyses. Compounds 1 and 6 showed appreciable inhibitory activity against HIV-1 protease with IC50 values of 50 and 20 μM, respectively.

AB - Three new lignans, longipedunins A (1), B (2) and C (3), together with three known compounds, benzoyl-binankadsurin A (4), acetyl-binankadsurin A (5) and schisanlactone A (6), were isolated from Kadsura longipedunculata. Their structures and stereochemistry were determined by spectral and single-crystal X-ray analyses. Compounds 1 and 6 showed appreciable inhibitory activity against HIV-1 protease with IC50 values of 50 and 20 μM, respectively.

KW - HIV-1 protease

KW - Kadsura longipedunculata

KW - Lignan

KW - Longipedunin

KW - X-ray crystal structure

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SN - 0009-2363

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JO - Chemical and Pharmaceutical Bulletin

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Three new lignans, longipedunins A-C, from Kadsura longipedunculata and their inhibitory activity against HIV-1 protease

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