@article{7050076be9d247e7ae5f33946f34f49a,
title = "The role of TNF-alpha and its receptors in the production of NGF and GDNF by astrocytes",
abstract = "The neurotrophic factors, nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF), are produced by astrocytes, and are induced by inflammatory stimuli including bacterial lipopolysaccharide and pro-inflammatory cytokines. In this study, we examined the regulatory mechanisms of tumor necrosis factor-α (TNF-α)-induced production of neurotrophic factors. We show here that cultured astrocytes express both TNF-α receptor 1 (TNFR1) and TNFR2, and that activation of these receptors by TNF-α promotes expression of both NGF and GDNF. In addition, we observe that not only exogenous TNF-α but also TNF-α produced by astrocytes induce NGF and GDNF production in astrocytes. These results suggest that an autocrine loop involving TNF-α contributes to the production of neurotrophic factors in response to inflammation.",
keywords = "Astrocyte, GDNF, NGF, Tumor necrosis factor-α",
author = "Reiko Kuno and Yusuke Yoshida and Atsumi Nitta and Toshitaka Nabeshima and Jinyan Wang and Yoshifumi Sonobe and Jun Kawanokuchi and Hideyuki Takeuchi and Tetsuya Mizuno and Akio Suzumura",
note = "Funding Information: This work was supported in part by the Neuroimmunological Disease Research Committee grant from the Ministry of Health, Labour, and Welfare of Japan, and a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology. This work was also supported by the 21st COE Program “Integrated Molecular Medicine for Neuronal and Neoplastic Disorders” from the Ministry of Education, Culture, Sports, Science, and Technology.",
year = "2006",
month = oct,
day = "20",
doi = "10.1016/j.brainres.2006.07.120",
language = "英語",
volume = "1116",
pages = "12--18",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier B.V.",
number = "1",
}