The role of TNF-alpha and its receptors in the production of NGF and GDNF by astrocytes

Reiko Kuno; Yusuke Yoshida; Atsumi Nitta; Toshitaka Nabeshima; Jinyan Wang; Yoshifumi Sonobe; Jun Kawanokuchi; Hideyuki Takeuchi; Tetsuya Mizuno; Akio Suzumura

doi:10.1016/j.brainres.2006.07.120

The role of TNF-alpha and its receptors in the production of NGF and GDNF by astrocytes

Reiko Kuno, Yusuke Yoshida, Atsumi Nitta, Toshitaka Nabeshima, Jinyan Wang, Yoshifumi Sonobe, Jun Kawanokuchi, Hideyuki Takeuchi, Tetsuya Mizuno, Akio Suzumura^*

^*Corresponding author for this work

Pharmaceutical Therapy and Neuropharmacology

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Abstract

The neurotrophic factors, nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF), are produced by astrocytes, and are induced by inflammatory stimuli including bacterial lipopolysaccharide and pro-inflammatory cytokines. In this study, we examined the regulatory mechanisms of tumor necrosis factor-α (TNF-α)-induced production of neurotrophic factors. We show here that cultured astrocytes express both TNF-α receptor 1 (TNFR1) and TNFR2, and that activation of these receptors by TNF-α promotes expression of both NGF and GDNF. In addition, we observe that not only exogenous TNF-α but also TNF-α produced by astrocytes induce NGF and GDNF production in astrocytes. These results suggest that an autocrine loop involving TNF-α contributes to the production of neurotrophic factors in response to inflammation.

Original language	English
Pages (from-to)	12-18
Number of pages	7
Journal	Brain Research
Volume	1116
Issue number	1
DOIs	https://doi.org/10.1016/j.brainres.2006.07.120
State	Published - 2006/10/20

Keywords

Astrocyte
GDNF
NGF
Tumor necrosis factor-α

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/j.brainres.2006.07.120

Cite this

@article{7050076be9d247e7ae5f33946f34f49a,

title = "The role of TNF-alpha and its receptors in the production of NGF and GDNF by astrocytes",

abstract = "The neurotrophic factors, nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF), are produced by astrocytes, and are induced by inflammatory stimuli including bacterial lipopolysaccharide and pro-inflammatory cytokines. In this study, we examined the regulatory mechanisms of tumor necrosis factor-α (TNF-α)-induced production of neurotrophic factors. We show here that cultured astrocytes express both TNF-α receptor 1 (TNFR1) and TNFR2, and that activation of these receptors by TNF-α promotes expression of both NGF and GDNF. In addition, we observe that not only exogenous TNF-α but also TNF-α produced by astrocytes induce NGF and GDNF production in astrocytes. These results suggest that an autocrine loop involving TNF-α contributes to the production of neurotrophic factors in response to inflammation.",

keywords = "Astrocyte, GDNF, NGF, Tumor necrosis factor-α",

author = "Reiko Kuno and Yusuke Yoshida and Atsumi Nitta and Toshitaka Nabeshima and Jinyan Wang and Yoshifumi Sonobe and Jun Kawanokuchi and Hideyuki Takeuchi and Tetsuya Mizuno and Akio Suzumura",

note = "Funding Information: This work was supported in part by the Neuroimmunological Disease Research Committee grant from the Ministry of Health, Labour, and Welfare of Japan, and a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology. This work was also supported by the 21st COE Program “Integrated Molecular Medicine for Neuronal and Neoplastic Disorders” from the Ministry of Education, Culture, Sports, Science, and Technology.",

year = "2006",

month = oct,

day = "20",

doi = "10.1016/j.brainres.2006.07.120",

language = "英語",

volume = "1116",

pages = "12--18",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - The role of TNF-alpha and its receptors in the production of NGF and GDNF by astrocytes

AU - Kuno, Reiko

AU - Yoshida, Yusuke

AU - Nitta, Atsumi

AU - Nabeshima, Toshitaka

AU - Wang, Jinyan

AU - Sonobe, Yoshifumi

AU - Kawanokuchi, Jun

AU - Takeuchi, Hideyuki

AU - Mizuno, Tetsuya

AU - Suzumura, Akio

N1 - Funding Information: This work was supported in part by the Neuroimmunological Disease Research Committee grant from the Ministry of Health, Labour, and Welfare of Japan, and a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology. This work was also supported by the 21st COE Program “Integrated Molecular Medicine for Neuronal and Neoplastic Disorders” from the Ministry of Education, Culture, Sports, Science, and Technology.

PY - 2006/10/20

Y1 - 2006/10/20

N2 - The neurotrophic factors, nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF), are produced by astrocytes, and are induced by inflammatory stimuli including bacterial lipopolysaccharide and pro-inflammatory cytokines. In this study, we examined the regulatory mechanisms of tumor necrosis factor-α (TNF-α)-induced production of neurotrophic factors. We show here that cultured astrocytes express both TNF-α receptor 1 (TNFR1) and TNFR2, and that activation of these receptors by TNF-α promotes expression of both NGF and GDNF. In addition, we observe that not only exogenous TNF-α but also TNF-α produced by astrocytes induce NGF and GDNF production in astrocytes. These results suggest that an autocrine loop involving TNF-α contributes to the production of neurotrophic factors in response to inflammation.

AB - The neurotrophic factors, nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF), are produced by astrocytes, and are induced by inflammatory stimuli including bacterial lipopolysaccharide and pro-inflammatory cytokines. In this study, we examined the regulatory mechanisms of tumor necrosis factor-α (TNF-α)-induced production of neurotrophic factors. We show here that cultured astrocytes express both TNF-α receptor 1 (TNFR1) and TNFR2, and that activation of these receptors by TNF-α promotes expression of both NGF and GDNF. In addition, we observe that not only exogenous TNF-α but also TNF-α produced by astrocytes induce NGF and GDNF production in astrocytes. These results suggest that an autocrine loop involving TNF-α contributes to the production of neurotrophic factors in response to inflammation.

KW - Astrocyte

KW - GDNF

KW - NGF

KW - Tumor necrosis factor-α

UR - http://www.scopus.com/inward/record.url?scp=33749246536&partnerID=8YFLogxK

U2 - 10.1016/j.brainres.2006.07.120

DO - 10.1016/j.brainres.2006.07.120

M3 - 学術論文

C2 - 16956589

AN - SCOPUS:33749246536

SN - 0006-8993

VL - 1116

SP - 12

EP - 18

JO - Brain Research

JF - Brain Research

IS - 1

ER -

The role of TNF-alpha and its receptors in the production of NGF and GDNF by astrocytes

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this