TY - JOUR
T1 - Targeting of TAK1 in inflammatory disorders and cancer
AU - Sakurai, Hiroaki
N1 - Funding Information:
This work was supported in part by Grants-in-Aid for Scientific Research on Innovative Areas and Scientific Research (C) from the Ministry of Education, Culture, Sports, Science and Technology, Japan, and grants from the Naito Memorial Foundation.
PY - 2012/10
Y1 - 2012/10
N2 - The transcription factors nuclear factor-κB (NF-κB) and activating protein-1 (AP-1) are critical regulators of stress responses, immunity, inflammation and cancer. A large variety of cellular stimuli utilize these signaling pathways through a common upstream kinase transforming growth factor-β-activated kinase 1 (TAK1). TAK1 was originally identified as a mitogen-activated kinase kinase kinase (MAP3K) activated by transforming growth factor-β (TGF-β); however, it has been characterized as a key regulator in inflammatory and immune signaling pathways. In addition, microbial proteins and components of host cell signaling scramble for the TAK1 complex in innate immunity. This review highlights the recent advances in the activation mechanisms and physiological functions of TAK1. Research targeting TAK1 raises the potential for new therapeutic options for inflammatory disorders, including cancer.
AB - The transcription factors nuclear factor-κB (NF-κB) and activating protein-1 (AP-1) are critical regulators of stress responses, immunity, inflammation and cancer. A large variety of cellular stimuli utilize these signaling pathways through a common upstream kinase transforming growth factor-β-activated kinase 1 (TAK1). TAK1 was originally identified as a mitogen-activated kinase kinase kinase (MAP3K) activated by transforming growth factor-β (TGF-β); however, it has been characterized as a key regulator in inflammatory and immune signaling pathways. In addition, microbial proteins and components of host cell signaling scramble for the TAK1 complex in innate immunity. This review highlights the recent advances in the activation mechanisms and physiological functions of TAK1. Research targeting TAK1 raises the potential for new therapeutic options for inflammatory disorders, including cancer.
UR - http://www.scopus.com/inward/record.url?scp=84866731086&partnerID=8YFLogxK
U2 - 10.1016/j.tips.2012.06.007
DO - 10.1016/j.tips.2012.06.007
M3 - 総説
C2 - 22795313
AN - SCOPUS:84866731086
SN - 0165-6147
VL - 33
SP - 522
EP - 530
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 10
ER -
