Synthesis of sominone and its derivatives based on an RCM strategy: Discovery of a novel anti-alzheimer's disease medicine candidate "denosomin"

Yuji Matsuya; Yu Ichiro Yamakawa; Chihiro Tohda; Kiyoshi Teshigawara; Masashi Yamada; Hideo Nemoto

doi:10.1021/ol901553w

Synthesis of sominone and its derivatives based on an RCM strategy: Discovery of a novel anti-alzheimer's disease medicine candidate "denosomin"

Yuji Matsuya^*, Yu Ichiro Yamakawa, Chihiro Tohda, Kiyoshi Teshigawara, Masashi Yamada, Hideo Nemoto

^*この論文の責任著者

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

37 被引用数 (Scopus)

抄録

(Figure Presrnted) Synthesis of sominone was achieved starting from dehydroepiandrosterone on the basis of an RCM strategy for the construction of a δ-lactone side chain. This synthetic protocol was applied for the synthesis of several analogous derivatives including 1-deoxy-24-norsominone (denosomin), which was revealed to exhibit notable bioactivities for new antidementia chemotherapy, exceeding the original natural compound sominone.

本文言語	英語
ページ（範囲）	3970-3973
ページ数	4
ジャーナル	Organic Letters
巻	11
号	17
DOI	https://doi.org/10.1021/ol901553w
出版ステータス	出版済み - 2009/09/03

ASJC Scopus 主題領域

生化学
物理化学および理論化学
有機化学

文献へのアクセス

10.1021/ol901553w

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引用スタイル

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abstract = "(Figure Presrnted) Synthesis of sominone was achieved starting from dehydroepiandrosterone on the basis of an RCM strategy for the construction of a δ-lactone side chain. This synthetic protocol was applied for the synthesis of several analogous derivatives including 1-deoxy-24-norsominone (denosomin), which was revealed to exhibit notable bioactivities for new antidementia chemotherapy, exceeding the original natural compound sominone.",

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AU - Tohda, Chihiro

AU - Teshigawara, Kiyoshi

AU - Yamada, Masashi

AU - Nemoto, Hideo

PY - 2009/9/3

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AB - (Figure Presrnted) Synthesis of sominone was achieved starting from dehydroepiandrosterone on the basis of an RCM strategy for the construction of a δ-lactone side chain. This synthetic protocol was applied for the synthesis of several analogous derivatives including 1-deoxy-24-norsominone (denosomin), which was revealed to exhibit notable bioactivities for new antidementia chemotherapy, exceeding the original natural compound sominone.

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