Synthesis of mutagenic 2,4‐dinitro‐[7‐14C]benzaldehyde

Miki Shoji; Masa‐Aki ‐A Mori; Michio Sayama; Hiroshi Kozuka; Takashi Honda

doi:10.1002/jlcr.2580340703

Synthesis of mutagenic 2,4‐dinitro‐[7‐¹⁴C]benzaldehyde

Miki Shoji^*, Masa‐Aki ‐A Mori, Michio Sayama, Hiroshi Kozuka, Takashi Honda

^*この論文の責任著者

工学科　生命工学コース

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

抄録

2,4‐Dinitro‐[7‐¹⁴C]benzaldehyde (4), a mutagenic substance which may have an unique metabolic activating pathways, was synthesized as a tracer for the detection of adducts of 4 with macromolecules. The preparation was performed in four steps from [7‐¹⁴C]toluene to give an overall radiochemical yield of 20% after purifying by TLC. The radiochemical purity was over 98%.

本文言語	英語
ページ（範囲）	597-601
ページ数	5
ジャーナル	Journal of Labelled Compounds and Radiopharmaceuticals
巻	34
号	7
DOI	https://doi.org/10.1002/jlcr.2580340703
出版ステータス	出版済み - 1994/07

ASJC Scopus 主題領域

分析化学
生化学
放射線学、核医学およびイメージング
創薬
分光学
有機化学

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10.1002/jlcr.2580340703

引用スタイル

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title = "Synthesis of mutagenic 2,4‐dinitro‐[7‐14C]benzaldehyde",

abstract = "2,4‐Dinitro‐[7‐14C]benzaldehyde (4), a mutagenic substance which may have an unique metabolic activating pathways, was synthesized as a tracer for the detection of adducts of 4 with macromolecules. The preparation was performed in four steps from [7‐14C]toluene to give an overall radiochemical yield of 20% after purifying by TLC. The radiochemical purity was over 98%.",

keywords = "2,4‐dinitro‐[7‐C]benzaldehyde, mutagen",

author = "Miki Shoji and Mori, {Masa‐Aki ‐A} and Michio Sayama and Hiroshi Kozuka and Takashi Honda",

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doi = "10.1002/jlcr.2580340703",

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T1 - Synthesis of mutagenic 2,4‐dinitro‐[7‐14C]benzaldehyde

AU - Shoji, Miki

AU - Mori, Masa‐Aki ‐A

AU - Sayama, Michio

AU - Kozuka, Hiroshi

AU - Honda, Takashi

PY - 1994/7

Y1 - 1994/7

N2 - 2,4‐Dinitro‐[7‐14C]benzaldehyde (4), a mutagenic substance which may have an unique metabolic activating pathways, was synthesized as a tracer for the detection of adducts of 4 with macromolecules. The preparation was performed in four steps from [7‐14C]toluene to give an overall radiochemical yield of 20% after purifying by TLC. The radiochemical purity was over 98%.

AB - 2,4‐Dinitro‐[7‐14C]benzaldehyde (4), a mutagenic substance which may have an unique metabolic activating pathways, was synthesized as a tracer for the detection of adducts of 4 with macromolecules. The preparation was performed in four steps from [7‐14C]toluene to give an overall radiochemical yield of 20% after purifying by TLC. The radiochemical purity was over 98%.

KW - 2,4‐dinitro‐[7‐C]benzaldehyde

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DO - 10.1002/jlcr.2580340703

M3 - 学術論文

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JF - Journal of Labelled Compounds and Radiopharmaceuticals

IS - 7

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Synthesis of mutagenic 2,4‐dinitro‐[7‐14C]benzaldehyde

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ASJC Scopus 主題領域

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引用スタイル

Synthesis of mutagenic 2,4‐dinitro‐[7‐¹⁴C]benzaldehyde