Synthesis of mutagenic 2,4‐dinitro‐[7‐14C]benzaldehyde

Miki Shoji; Masa‐Aki ‐A Mori; Michio Sayama; Hiroshi Kozuka; Takashi Honda

doi:10.1002/jlcr.2580340703

Synthesis of mutagenic 2,4‐dinitro‐[7‐¹⁴C]benzaldehyde

Miki Shoji^*, Masa‐Aki ‐A Mori, Michio Sayama, Hiroshi Kozuka, Takashi Honda

^*Corresponding author for this work

Life Sciences and Bioengineering

Research output: Contribution to journal › Article › peer-review

Abstract

2,4‐Dinitro‐[7‐¹⁴C]benzaldehyde (4), a mutagenic substance which may have an unique metabolic activating pathways, was synthesized as a tracer for the detection of adducts of 4 with macromolecules. The preparation was performed in four steps from [7‐¹⁴C]toluene to give an overall radiochemical yield of 20% after purifying by TLC. The radiochemical purity was over 98%.

Original language	English
Pages (from-to)	597-601
Number of pages	5
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	34
Issue number	7
DOIs	https://doi.org/10.1002/jlcr.2580340703
State	Published - 1994/07

Keywords

2,4‐dinitro‐[7‐C]benzaldehyde
mutagen

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

Access to Document

10.1002/jlcr.2580340703

Cite this

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title = "Synthesis of mutagenic 2,4‐dinitro‐[7‐14C]benzaldehyde",

abstract = "2,4‐Dinitro‐[7‐14C]benzaldehyde (4), a mutagenic substance which may have an unique metabolic activating pathways, was synthesized as a tracer for the detection of adducts of 4 with macromolecules. The preparation was performed in four steps from [7‐14C]toluene to give an overall radiochemical yield of 20% after purifying by TLC. The radiochemical purity was over 98%.",

keywords = "2,4‐dinitro‐[7‐C]benzaldehyde, mutagen",

author = "Miki Shoji and Mori, {Masa‐Aki ‐A} and Michio Sayama and Hiroshi Kozuka and Takashi Honda",

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AU - Sayama, Michio

AU - Kozuka, Hiroshi

AU - Honda, Takashi

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N2 - 2,4‐Dinitro‐[7‐14C]benzaldehyde (4), a mutagenic substance which may have an unique metabolic activating pathways, was synthesized as a tracer for the detection of adducts of 4 with macromolecules. The preparation was performed in four steps from [7‐14C]toluene to give an overall radiochemical yield of 20% after purifying by TLC. The radiochemical purity was over 98%.

AB - 2,4‐Dinitro‐[7‐14C]benzaldehyde (4), a mutagenic substance which may have an unique metabolic activating pathways, was synthesized as a tracer for the detection of adducts of 4 with macromolecules. The preparation was performed in four steps from [7‐14C]toluene to give an overall radiochemical yield of 20% after purifying by TLC. The radiochemical purity was over 98%.

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