Synthesis of Denosomin-Vitamin D3 Hybrids and Evaluation of Their Anti-Alzheimer's Disease Activities

Kenji Sugimoto, Hisanari Yajima, Yusuke Hayashi, Daishiro Minato, Sayuri Terasaki, Chihiro Tohda, Yuji Matsuya*

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

11 被引用数 (Scopus)

抄録

As an extension of previously conducted studies on developing an anti-Alzheimer's disease agent, denosomin (1-deoxy-24-norsominone, an artificial inducer of neurite elongation), derivatives were designed and synthesized based on the hypothesis that our denosomin would exhibit axonal extension activity via a 1,25D3-membrane-associated, rapid response steroid-binding protein (1,25D3-MARRS) pathway. The biological assay revealed that the hybridization of characteristic δ-lactone in denosomin and the triene moiety in VD3 was effective to enhance the nerve re-extension activity in amyloid β (Aβ)-damaged neurons.

本文言語英語
ページ(範囲)5910-5913
ページ数4
ジャーナルOrganic Letters
17
23
DOI
出版ステータス出版済み - 2015/11/20

ASJC Scopus 主題領域

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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