抄録
As an extension of previously conducted studies on developing an anti-Alzheimer's disease agent, denosomin (1-deoxy-24-norsominone, an artificial inducer of neurite elongation), derivatives were designed and synthesized based on the hypothesis that our denosomin would exhibit axonal extension activity via a 1,25D3-membrane-associated, rapid response steroid-binding protein (1,25D3-MARRS) pathway. The biological assay revealed that the hybridization of characteristic δ-lactone in denosomin and the triene moiety in VD3 was effective to enhance the nerve re-extension activity in amyloid β (Aβ)-damaged neurons.
本文言語 | 英語 |
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ページ(範囲) | 5910-5913 |
ページ数 | 4 |
ジャーナル | Organic Letters |
巻 | 17 |
号 | 23 |
DOI | |
出版ステータス | 出版済み - 2015/11/20 |
ASJC Scopus 主題領域
- 生化学
- 物理化学および理論化学
- 有機化学