@article{d2f2814a954d465aa31179f4215e7d98,
title = "Synthesis of 2-acetamido-1,2-dideoxy-d-galacto-nojirimycin [DGJNAc] from d-glucuronolactone: the first sub-micromolar inhibitor of α-N-acetylgalactosaminidases",
abstract = "2-Acetamido-1,2-dideoxy-d-galacto-nojirimycin [DGJNAc], prepared in 20% overall yield from d-glucuronolactone, is the first potent competitive sub-micromolar inhibitor of α-N-acetyl-galactosaminidases (Ki 0.081 μM from chicken liver, Ki 0.136 μM from Charonia lampas). DGJNAc is a good competitive-whereas the enantiomer l-DGJNAc is a very weak but non-competitive-inhibitor of β-hexosaminidases.",
author = "Daniel Best and Phoom Chairatana and Glawar, {Andreas F.G.} and Elizabeth Crabtree and Butters, {Terry D.} and Wilson, {Francis X.} and Yu, {Chu Yi} and Wang, {Wu Bao} and Jia, {Yue Mei} and Isao Adachi and Atsushi Kato and Fleet, {George W.J.}",
note = "Funding Information: Support from a Nuffield Foundation Undergraduate Research Bursary [to P.C.] and Summit plc is gratefully acknowledged.",
year = "2010",
month = apr,
day = "28",
doi = "10.1016/j.tetlet.2010.02.063",
language = "英語",
volume = "51",
pages = "2222--2224",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Ltd.",
number = "17",
}