抄録
The first synthesis of 1,2-trans-homoiminosugars devised as mimics of I-d-GlcNAc and I-d-ManNAc is described. Key steps include a regioselective azidolysis of a cyclic sulfite and a I-amino alcohol skeletal rearrangement applied to a polyhydroxylated azepane. The I-d-GlcNAc derivative has been coupled to serine to deliver an iminosugar C-amino acid. The two homoiminosugars demonstrate moderate glycosidase inhibition.
本文言語 | 英語 |
---|---|
ページ(範囲) | 5516-5519 |
ページ数 | 4 |
ジャーナル | Organic Letters |
巻 | 16 |
号 | 21 |
DOI | |
出版ステータス | 出版済み - 2014/11/07 |
ASJC Scopus 主題領域
- 生化学
- 物理化学および理論化学
- 有機化学