Synthesis and evaluations of GLP-1 secretion and anti-diabetic effect in KKAy mice of new tricyclic compounds

Daisuke Minehira; Daisuke Takeda; Shota Miyawaki; Atsushi Kato; Isao Adachi; Akira Miyazaki; Ryuta Miyatake; Masahito Umezaki; Kyoko Miura; Yoshiro Kitahara; Kenji Sugimoto; Yuji Matsuya; Naoki Toyooka

doi:10.3987/COM-14-S(K)29

Synthesis and evaluations of GLP-1 secretion and anti-diabetic effect in KKAy mice of new tricyclic compounds

Daisuke Minehira, Daisuke Takeda, Shota Miyawaki, Atsushi Kato, Isao Adachi, Akira Miyazaki, Ryuta Miyatake, Masahito Umezaki, Kyoko Miura, Yoshiro Kitahara, Kenji Sugimoto, Yuji Matsuya, Naoki Toyooka^*

^*この論文の責任著者

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

抄録

Glucagon-like peptide-1 (GLP-1), which belongs to the family of incretins, plays important role for the regulation of plasma glucose. Accordingly, GLP-1-based therapies for type 2 diabetes have recognized as one of the most interesting target. In this study, we have found the new tricyclic compounds having strong GLP-1 secretion from human intestinal L cells, and anti-diabetic properties in spontaneously obese and diabetic KKAy mice. The most potent compound 5ka was obtained as the unexpected product, and we would like to report the details of the synthesis, structure elucidations, pharmacological activities on secretion of GLP-1, and anti-diabetic effects using diabetic KKAy mice.

本文言語	英語
ページ（範囲）	372-404
ページ数	33
ジャーナル	Heterocycles
巻	90
号	1
DOI	https://doi.org/10.3987/COM-14-S(K)29
出版ステータス	出版済み - 2015

ASJC Scopus 主題領域

分析化学
薬理学
有機化学

UN SDG

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10.3987/COM-14-S(K)29

引用スタイル

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title = "Synthesis and evaluations of GLP-1 secretion and anti-diabetic effect in KKAy mice of new tricyclic compounds",

abstract = "Glucagon-like peptide-1 (GLP-1), which belongs to the family of incretins, plays important role for the regulation of plasma glucose. Accordingly, GLP-1-based therapies for type 2 diabetes have recognized as one of the most interesting target. In this study, we have found the new tricyclic compounds having strong GLP-1 secretion from human intestinal L cells, and anti-diabetic properties in spontaneously obese and diabetic KKAy mice. The most potent compound 5ka was obtained as the unexpected product, and we would like to report the details of the synthesis, structure elucidations, pharmacological activities on secretion of GLP-1, and anti-diabetic effects using diabetic KKAy mice.",

author = "Daisuke Minehira and Daisuke Takeda and Shota Miyawaki and Atsushi Kato and Isao Adachi and Akira Miyazaki and Ryuta Miyatake and Masahito Umezaki and Kyoko Miura and Yoshiro Kitahara and Kenji Sugimoto and Yuji Matsuya and Naoki Toyooka",

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doi = "10.3987/COM-14-S(K)29",

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AU - Minehira, Daisuke

AU - Takeda, Daisuke

AU - Miyawaki, Shota

AU - Kato, Atsushi

AU - Adachi, Isao

AU - Miyazaki, Akira

AU - Miyatake, Ryuta

AU - Umezaki, Masahito

AU - Miura, Kyoko

AU - Kitahara, Yoshiro

AU - Sugimoto, Kenji

AU - Matsuya, Yuji

AU - Toyooka, Naoki

PY - 2015

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AB - Glucagon-like peptide-1 (GLP-1), which belongs to the family of incretins, plays important role for the regulation of plasma glucose. Accordingly, GLP-1-based therapies for type 2 diabetes have recognized as one of the most interesting target. In this study, we have found the new tricyclic compounds having strong GLP-1 secretion from human intestinal L cells, and anti-diabetic properties in spontaneously obese and diabetic KKAy mice. The most potent compound 5ka was obtained as the unexpected product, and we would like to report the details of the synthesis, structure elucidations, pharmacological activities on secretion of GLP-1, and anti-diabetic effects using diabetic KKAy mice.

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SN - 0385-5414

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Synthesis and evaluations of GLP-1 secretion and anti-diabetic effect in KKAy mice of new tricyclic compounds

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ASJC Scopus 主題領域

UN SDG

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